HitPredict

Interactor 1: BAG6 (P46379)
Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe)
Gene: BAG6

Interactor 2: SGTB (Q96EQ0)
Small glutamine-rich tetratricopeptide repeat-containing protein beta (Beta-SGT) (Small glutamine-rich protein with tetratricopeptide repeats 2)
Gene: SGTB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SGTA_dimer~ubiquitin
Common GO terms	GO:0006620 - post-translational protein targeting to endoplasmic reticulum membrane GO:0016020 - membrane GO:0030544 - Hsp70 protein binding GO:0060090 - molecular adaptor activity
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1132 Hs			1 304
+	Hs
		213499 BAG6_HUMAN (1-1132): 0: 597: 100.00		SGTA_HUMAN (1-303): 5.48e-58: 190: 57.56
+	Hs
		803808 BAG6_HUMAN (1-1132): 0: 597: 100.00		CHIP_HUMAN (63-222): 5.78e-40: 143: 26.67
+	Hs
		803628 BAG6_HUMAN (1-1132): 0: 597: 100.00		TMTC1_HUMAN (1-211): 5.37e-28: 115: 15.81
+	Hs
		684492 BAG6_HUMAN (1-1132): 0: 597: 100.00		STIP1_HUMAN (36-217): 3.46e-22: 98.4: 22.22
+	Hs
		213665 UBQL2_HUMAN (13-587): 2.27e-26: 117: 14.71		SGTA_HUMAN (1-303): 5.48e-58: 190: 57.56
+	Hs
		213522 RS27A_HUMAN (17-87): 2.18e-27: 111: 34.72		SGTA_HUMAN (1-303): 5.48e-58: 190: 57.56
+	Hs
		213523 RL40_HUMAN (17-87): 9.53e-28: 111: 34.72		SGTA_HUMAN (1-303): 5.48e-58: 190: 57.56
+	Hs
		684553 SC24C_HUMAN (380-696): 1.27e-39: 162: 24.18		STIP1_HUMAN (36-217): 3.46e-22: 98.4: 22.22
+	Mm
		924235 RS27A_MOUSE (17-87): 2.18e-27: 111: 34.72		PPP5_MOUSE (64-239): 1.31e-38: 143: 24.86
+	Hs
		924436 RL40_HUMAN (17-87): 9.53e-28: 111: 34.72		CHIP_HUMAN (63-222): 5.78e-40: 143: 26.67
+	Hs
		672870 CBP_HUMAN (204-749): 1.19e-09: 65.1: 12.25		CDC27_HUMAN (6-239): 5.08e-27: 112: 15.39
+	Hs
		175053 KMT2C_HUMAN (269-805): 1.24e-13: 78.2: 9.11		OGT1_HUMAN (79-288): 8e-22: 97.6: 13.33
+	Hs
		175080 CBP_HUMAN (204-749): 1.19e-09: 65.1: 12.25		OGT1_HUMAN (79-288): 8e-22: 97.6: 13.33
+	At
		1114641 RL40B_ARATH (17-87): 6.85e-12: 65.6: 34.72		CHIP_ARATH (85-182): 6.75e-17: 80.9: 42.86