HitPredict

Interactor 1: IL6RB (P40189)
Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
Gene: IL6ST

Interactor 2: RAC3 (P60763)
Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3)
Gene: RAC3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0043025 - neuronal cell body GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 918 Hs			1 192
+	Hs
		820527 IL6RB_HUMAN (1-918): 0: 626: 100.00		RAC1_HUMAN (1-192): 2.11e-85: 251: 92.71
+	Hs
		580907 IL6RB_HUMAN (1-918): 0: 626: 100.00		RAC2_HUMAN (1-192): 9.15e-82: 242: 88.54
+	Hs
		820543 IL6RB_HUMAN (1-918): 0: 626: 100.00		RHOJ_HUMAN (2-190): 2.65e-80: 239: 60.32
+	Hs
		820528 IL6RB_HUMAN (1-918): 0: 626: 100.00		RHOG_HUMAN (1-192): 1.04e-78: 234: 69.79
+	Hs
		820522 IL6RB_HUMAN (1-918): 0: 626: 100.00		CDC42_HUMAN (1-192): 1.05e-77: 231: 68.75
+	Hs
		820523 IL6RB_HUMAN (1-918): 0: 626: 100.00		RHOA_HUMAN (5-192): 9.22e-77: 229: 55.32
+	Hs
		466134 IL6RB_HUMAN (1-918): 0: 626: 100.00		RHOC_HUMAN (5-192): 2.47e-74: 223: 54.79
+	Hs
		601195 IL6RB_HUMAN (1-918): 0: 626: 100.00		RHOQ_HUMAN (4-189): 1.68e-72: 219: 63.49
+	Hs
		988647 OSMR_HUMAN (30-841): 2.04e-101: 340: 18.93		RAC1_HUMAN (1-192): 2.11e-85: 251: 92.71
+	Hs
		1406209 OSMR_HUMAN (30-841): 2.04e-101: 340: 18.93		RHOJ_HUMAN (2-190): 2.65e-80: 239: 60.32
+	Hs
		953634 OSMR_HUMAN (30-841): 2.04e-101: 340: 18.93		RAC3_HUMAN (1-192): 5.48e-80: 238: 100.00
+	Hs
		466431 OSMR_HUMAN (30-841): 2.04e-101: 340: 18.93		RHOC_HUMAN (5-192): 2.47e-74: 223: 54.79
+	Hs
		988333 PTPRS_HUMAN (26-882): 2.13e-68: 251: 12.38		RAC1_HUMAN (1-192): 2.11e-85: 251: 92.71
+	Hs
		1102754 PTPRS_HUMAN (26-882): 2.13e-68: 251: 12.38		RHOJ_HUMAN (2-190): 2.65e-80: 239: 60.32
+	Hs
		953423 PTPRS_HUMAN (26-882): 2.13e-68: 251: 12.38		RAC3_HUMAN (1-192): 5.48e-80: 238: 100.00
+	Hs
		955122 PTPRS_HUMAN (26-882): 2.13e-68: 251: 12.38		CDC42_HUMAN (1-192): 1.05e-77: 231: 68.75
+	Hs
		962011 PTPRS_HUMAN (26-882): 2.13e-68: 251: 12.38		RHOA_HUMAN (5-192): 9.22e-77: 229: 55.32
+	Hs
		466235 PTPRS_HUMAN (26-882): 2.13e-68: 251: 12.38		RHOC_HUMAN (5-192): 2.47e-74: 223: 54.79
+	Hs
		601268 PTPRS_HUMAN (26-882): 2.13e-68: 251: 12.38		RHOQ_HUMAN (4-189): 1.68e-72: 219: 63.49
+	Hs
		466080 PTPRF_HUMAN (129-917): 2.54e-64: 239: 12.96		RHOC_HUMAN (5-192): 2.47e-74: 223: 54.79