HitPredict

Interactor 1: PRS4 (P48601)
26S proteasome regulatory subunit 4 (P26s4)
Gene: Rpt2

Interactor 2: Q9VW54 (Q9VW54)
26S proteasome non-ATPase regulatory subunit 2
Gene: Rpn1

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.67	1.00	0.822

Property	Details
Experiments	37061542, 22036573, 19079254
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	AAA_lid_3~RPN1_C, AAA_lid_3~RPN1_RPN2_N
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005838 - proteasome regulatory particle GO:0008540 - proteasome regulatory particle, base subcomplex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 439 Dm			1 919
+	Hs
		1027680 Q53HB3_HUMAN (24-439): 5.35e-138: 404: 92.79		PSMD2_HUMAN (3-917): 0: 1154: 60.89
+	Hs
		1027683 Q53XL8_HUMAN (24-439): 8.92e-138: 404: 92.55		PSMD2_HUMAN (3-917): 0: 1154: 60.89
+	Hs
		906819 PRS4_HUMAN (24-439): 8.92e-138: 404: 92.55		PSMD2_HUMAN (3-917): 0: 1154: 60.89
+	Hs
		66339 A8K2M0_HUMAN (49-432): 9.35e-130: 382: 48.18		PSMD2_HUMAN (3-917): 0: 1154: 60.89
+	Dm
		1374009 Q9VTQ9_DROME (49-433): 3.47e-127: 375: 41.30		Q9VW54_DROME (1-919): 0: 1058: 100.00
+	At
		1341456 PS10B_ARATH (39-433): 7.28e-143: 415: 41.52		PSD2A_ARATH (43-919): 0: 1005: 47.98
+	At
		1167708 PRS4A_ARATH (1-439): 4.1e-137: 402: 77.43		PSD2B_ARATH (43-919): 0: 1007: 47.65
+	At
		1352342 PRS4B_ARATH (1-439): 1.87e-137: 403: 77.88		PSD2A_ARATH (43-919): 0: 1005: 47.98
+	At
		1352344 PRS4A_ARATH (1-439): 4.1e-137: 402: 77.43		PSD2A_ARATH (43-919): 0: 1005: 47.98
+	Ce
		183866 PRS4_CAEEL (1-439): 9.42e-135: 396: 84.20		Q9GZH5_CAEEL (35-917): 0: 1005: 52.21
+	At
		1352075 PRS6B_ARATH (37-429): 1.66e-128: 379: 45.29		PSD2A_ARATH (43-919): 0: 1005: 47.98
+	Sc
		753896 PRS10_YEAST (9-436): 8.69e-144: 419: 37.82		RPN1_YEAST (47-919): 0: 879: 39.67
+	Sc
		753835 PRS4_YEAST (1-439): 7.64e-131: 386: 70.62		RPN1_YEAST (47-919): 0: 879: 39.67
+	Hs
		906907 PRS4_HUMAN (24-439): 8.92e-138: 404: 92.55		PSMD1_HUMAN (57-856): 0: 764: 17.41
+	At
		221383 PRS4A_ARATH (1-439): 4.1e-137: 402: 77.43		PSD1A_ARATH (57-855): 0: 740: 17.69
+	At
		1341469 PRS4A_ARATH (1-439): 4.1e-137: 402: 77.43		PSD1B_ARATH (57-855): 0: 730: 17.47
+	Dm
		820502 PRS4_DROME (1-439): 7.01e-141: 411: 100.00		PSMD1_DROME (57-856): 0: 664: 17.40
+	Sc
		693337 PRS10_YEAST (9-436): 8.69e-144: 419: 37.82		RPN2_YEAST (57-863): 0: 617: 17.52
+	Sp
		251844 PRS4_SCHPO (24-436): 6.09e-126: 374: 75.42		RPN2_SCHPO (57-855): 0: 629: 16.98
+	Sc
		693312 PRS4_YEAST (1-439): 7.64e-131: 386: 70.62		RPN2_YEAST (57-863): 0: 617: 17.52