HitPredict

Interactor 1: PRS4 (P48601)
26S proteasome regulatory subunit 4 (P26s4)
Gene: Rpt2

Interactor 2: Q9VTQ9 (Q9VTQ9)
AT06668p (Regulatory particle triple-A ATPase 4-related, isoform A) (Regulatory particle triple-A ATPase 4-related, isoform B (EC 5.6.1.5))
Gene: Rpt4R

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	19079254
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AAA~AAA, AAA~AAA_lid_3, AAA~Prot_ATP_ID_OB, AAA_lid_3~AAA_lid_3, Prot_ATP_ID_OB~Prot_ATP_ID_OB
Common GO terms	GO:0005524 - ATP binding GO:0008540 - proteasome regulatory particle, base subcomplex GO:0016887 - ATP hydrolysis activity GO:0036402 - proteasome-activating activity GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 439 Dm			1 398
+	Hs
		906800 PRS4_HUMAN (24-439): 8.92e-138: 404: 92.55		PRS4_HUMAN (4-389): 1.17e-136: 399: 41.71
+	Dm
		820504 PRS4_DROME (1-439): 7.01e-141: 411: 100.00		Q9V405_DROME (8-390): 1.12e-131: 385: 40.99
+	Hs
		798632 PRS4_HUMAN (24-439): 8.92e-138: 404: 92.55		PRS6B_HUMAN (9-390): 1.54e-131: 385: 41.10
+	Sc
		862672 PRS10_YEAST (9-436): 8.69e-144: 419: 37.82		PRS8_YEAST (22-393): 5.42e-104: 315: 45.16
+	Sc
		703936 PRS10_YEAST (9-436): 8.69e-144: 419: 37.82		PRS7_YEAST (78-395): 1.97e-102: 313: 47.96
+	Dm
		820484 PRS4_DROME (1-439): 7.01e-141: 411: 100.00		Q7KMQ0_DROME (78-383): 1.31e-102: 312: 48.37
+	Hs
		730232 PRS4_HUMAN (24-439): 8.92e-138: 404: 92.55		PRS7_HUMAN (78-383): 2.64e-102: 311: 48.69
+	Hs
		730278 Q53HB3_HUMAN (24-439): 5.35e-138: 404: 92.79		PRS7_HUMAN (78-383): 2.64e-102: 311: 48.69
+	Dm
		820486 PRS4_DROME (1-439): 7.01e-141: 411: 100.00		TERA_DROME (48-375): 4.6e-80: 263: 31.61
+	At
		870963 PRS4A_ARATH (1-439): 4.1e-137: 402: 77.43		CD48A_ARATH (125-375): 1.1e-80: 265: 39.04
+	Hs
		874772 PRS4_HUMAN (24-439): 8.92e-138: 404: 92.55		TERA_HUMAN (123-375): 6.36e-80: 263: 39.13
+	Dm
		186108 PRS4_DROME (1-439): 7.01e-141: 411: 100.00		PRS8_DROME (1-107): 6.51e-13: 71.7: 11.22
+	Dm
		820493 PRS4_DROME (1-439): 7.01e-141: 411: 100.00		Q8SZ19_DROME (1-115): 6.53e-13: 71.7: 10.44
+	Dm
		820534 PRS4_DROME (1-439): 7.01e-141: 411: 100.00		Q9W414_DROME (1-115): 6.07e-13: 71.7: 10.44
+	At
		1341457 PRS4A_ARATH (1-439): 4.1e-137: 402: 77.43		PS10B_ARATH (1-120): 1.88e-14: 76.3: 11.67
+	At
		1352074 PRS4A_ARATH (1-439): 4.1e-137: 402: 77.43		PS10A_ARATH (1-120): 2.53e-14: 75.9: 10.83
+	Hs
		906805 PRS4_HUMAN (24-439): 8.92e-138: 404: 92.55		PRS10_HUMAN (1-115): 1.73e-12: 70.2: 10.44
+	Hs
		906801 PRS4_HUMAN (24-439): 8.92e-138: 404: 92.55		PRS8_HUMAN (1-107): 2.86e-12: 69.8: 11.22
+	Rn
		906970 PRS4_RAT (24-439): 8.92e-138: 404: 92.55		PRS8_RAT (1-107): 2.86e-12: 69.8: 11.22
+	At
		1319804 PRS4A_ARATH (1-439): 4.1e-137: 402: 77.43		PRS8A_ARATH (1-107): 1.67e-11: 67.5: 14.02