HitPredict

Interactor 1: CTRO (P49025)
Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Rho-interacting, serine/threonine-protein kinase 21)
Gene: Cit

Interactor 2: RAC1 (P63001)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (p21-Rac1)
Gene: RAC1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	10493740
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras, Pkinase~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016358 - dendrite development
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2055 Mm			1 192
+	Rn
		92842 CTRO_RAT (1-2055): 0: 1282: 98.30		RHOA_RAT (5-192): 1.43e-77: 231: 57.98
+	Mm
		823529 CTRO_MOUSE (1-2055): 0: 1264: 100.00		CDC42_MOUSE (1-192): 1.4e-78: 234: 70.31
+	Mm
		823539 CTRO_MOUSE (1-2055): 0: 1264: 100.00		RHOA_MOUSE (5-192): 1.43e-77: 231: 57.98
+	Hs
		148653 CTRO_HUMAN (1-2055): 0: 1238: 92.03		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		148608 CTRO_HUMAN (1-2055): 0: 1238: 92.03		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		148297 CTRO_HUMAN (1-2055): 0: 1238: 92.03		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45
+	Hs
		925229 DMPK_HUMAN (57-547): 3.25e-119: 394: 34.20		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		564425 AKT2_HUMAN (30-404): 6.34e-119: 387: 30.55		RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67
+	Dm
		116376 M9PI41_DROME (599-1884): 1.32e-103: 372: 16.02		RHO1_DROME (5-192): 2.78e-75: 226: 59.04
+	Dm
		776923 Q9VXE3_DROME (636-1287): 8.32e-38: 158: 12.37		RAC1_DROME (1-192): 8.65e-83: 245: 91.67
+	Dm
		776931 X2JE40_DROME (636-1287): 1.08e-37: 158: 12.37		RAC1_DROME (1-192): 8.65e-83: 245: 91.67
+	Hs
		925766 MRCKB_HUMAN (615-1133): 2.62e-33: 143: 14.53		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		564758 MRCKB_HUMAN (615-1133): 2.62e-33: 143: 14.53		RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67
+	Hs
		545725 MRCKB_HUMAN (615-1133): 2.62e-33: 143: 14.53		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Dm
		816395 X2JE40_DROME (636-1287): 1.08e-37: 158: 12.37		RHO1_DROME (5-192): 2.78e-75: 226: 59.04
+	Dm
		816384 Q961D4_DROME (636-1287): 1.88e-37: 157: 12.37		RHO1_DROME (5-192): 2.78e-75: 226: 59.04
+	Hs
		892702 MRCKB_HUMAN (615-1133): 2.62e-33: 143: 14.53		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Hs
		951494 MRCKB_HUMAN (615-1133): 2.62e-33: 143: 14.53		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		894628 MRCKB_HUMAN (615-1133): 2.62e-33: 143: 14.53		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		901094 MRCKB_HUMAN (615-1133): 2.62e-33: 143: 14.53		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98