HitPredict

Interactor 1: MCM2 (P49736)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)
Gene: MCM2

Interactor 2: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	25963833, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~MCM2_N
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006334 - nucleosome assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 904 Hs			1 126
+	Hs
		832512 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B2F_HUMAN (1-126): 2.34e-54: 168: 97.62
+	Hs
		617935 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1O_HUMAN (1-126): 3.25e-54: 167: 99.21
+	Hs
		420814 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1J_HUMAN (1-126): 7.8e-54: 166: 99.21
+	Hs
		832322 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		832624 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41
+	Hs
		832673 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1M_HUMAN (1-126): 5.38e-54: 166: 96.03
+	Hs
		241476 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Hs
		707553 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		832280 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1D_HUMAN (1-126): 3.5e-53: 164: 98.41
+	Hs
		832671 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1N_HUMAN (1-126): 3.35e-53: 164: 98.41
+	Hs
		832674 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1L_HUMAN (1-126): 2.49e-52: 162: 97.62
+	Hs
		832577 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03
+	Hs
		832629 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2B1A_HUMAN (1-126): 3.43e-46: 147: 85.04
+	Hs
		708414 MCM4_HUMAN (2-885): 0: 847: 28.42		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		708456 MCM4_HUMAN (2-885): 0: 847: 28.42		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		241460 MCM4_HUMAN (2-885): 0: 847: 28.42		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Hs
		707531 MCM4_HUMAN (2-885): 0: 847: 28.42		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		708493 MCM4_HUMAN (2-885): 0: 847: 28.42		H2B1A_HUMAN (1-126): 3.43e-46: 147: 85.04
+	Sc
		355815 MCM2_YEAST (11-821): 0: 819: 46.70		H2B2_YEAST (3-125): 4.73e-37: 124: 71.55
+	Sc
		355382 MCM2_YEAST (11-821): 0: 819: 46.70		H2B1_YEAST (3-125): 1.81e-36: 122: 71.55