HitPredict

Interactor 1: MCM2 (P49736)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)
Gene: MCM2

Interactor 2: H32 (Q71DI3)
Histone H3.2 (H3-clustered histone 13) (H3-clustered histone 14) (H3-clustered histone 15) (Histone H3/m) (Histone H3/o)
Gene: H3C15

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	25963833, 26167883
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~MCM2_N
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006334 - nucleosome assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 904 Hs			1 136
+	Hs
		832357 MCM2_HUMAN (1-904): 0: 1078: 100.00		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Hs
		832495 MCM2_HUMAN (1-904): 0: 1078: 100.00		H31T_HUMAN (1-136): 8.3e-62: 187: 96.32
+	Hs
		832369 MCM2_HUMAN (1-904): 0: 1078: 100.00		H33_HUMAN (1-136): 1.59e-61: 186: 97.06
+	Mm
		935446 MCM2_MOUSE (1-904): 0: 1058: 95.58		H31_MOUSE (1-136): 1.98e-62: 189: 99.27
+	Mm
		952250 MCM2_MOUSE (1-904): 0: 1058: 95.58		H32_MOUSE (1-136): 3.73e-61: 186: 100.00
+	Mm
		952736 MCM2_MOUSE (1-904): 0: 1058: 95.58		H33_MOUSE (1-136): 1.59e-61: 186: 97.06
+	Hs
		828172 MCM2_HUMAN (1-904): 0: 1078: 100.00		CENPA_HUMAN (9-133): 2.85e-44: 143: 50.00
+	Hs
		708415 MCM4_HUMAN (2-885): 0: 847: 28.42		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Hs
		708421 MCM4_HUMAN (2-885): 0: 847: 28.42		H33_HUMAN (1-136): 1.59e-61: 186: 97.06
+	Sc
		667617 MCM2_YEAST (11-821): 0: 819: 46.70		H3_YEAST (1-136): 7.77e-56: 172: 88.97
+	Hs
		708398 MCM4_HUMAN (2-885): 0: 847: 28.42		CENPA_HUMAN (9-133): 2.85e-44: 143: 50.00
+	Sc
		667566 MCM2_YEAST (11-821): 0: 819: 46.70		CENPA_YEAST (18-134): 1.58e-41: 139: 56.67
+	Hs
		708603 MCM5_HUMAN (169-902): 0: 768: 29.43		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Hs
		708661 MCM5_HUMAN (169-902): 0: 768: 29.43		H31T_HUMAN (1-136): 8.3e-62: 187: 96.32
+	Hs
		708605 MCM5_HUMAN (169-902): 0: 768: 29.43		H33_HUMAN (1-136): 1.59e-61: 186: 97.06
+	Hs
		708690 MCM5_HUMAN (169-902): 0: 768: 29.43		H32_HUMAN (1-136): 3.73e-61: 186: 100.00
+	Hs
		708677 MCM5_HUMAN (169-902): 0: 768: 29.43		H37_HUMAN (1-136): 3.26e-59: 181: 97.06
+	Hs
		708683 MCM5_HUMAN (169-902): 0: 768: 29.43		H3C_HUMAN (1-136): 8.83e-59: 179: 94.12
+	Sc
		675545 MCM4_YEAST (7-889): 0: 764: 25.82		H3_YEAST (1-136): 7.77e-56: 172: 88.97
+	Sc
		675521 MCM4_YEAST (7-889): 0: 764: 25.82		CENPA_YEAST (18-134): 1.58e-41: 139: 56.67