HitPredict

Interactor 1: MCM2 (P49736)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)
Gene: MCM2

Interactor 2: H2A2B (Q8IUE6)
Histone H2A type 2-B (H2A-clustered histone 21)
Gene: H2AC21

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25963833
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~MCM2_N
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 904 Hs			1 130
+	Hs
		832655 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2A1A_HUMAN (1-129): 1.95e-68: 203: 92.25
+	Hs
		391599 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2A1B_HUMAN (1-130): 1e-67: 202: 93.85
+	Hs
		470300 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2A1_HUMAN (1-130): 8.04e-68: 202: 94.62
+	Hs
		594831 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2A1D_HUMAN (1-130): 9.47e-68: 202: 93.85
+	Hs
		832523 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2A2A_HUMAN (1-130): 5.07e-68: 202: 94.62
+	Hs
		832548 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2A3_HUMAN (1-130): 6.67e-68: 202: 94.62
+	Hs
		832623 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2A1C_HUMAN (1-130): 5.24e-68: 202: 95.39
+	Hs
		832648 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2A1H_HUMAN (1-128): 7.7e-68: 202: 95.31
+	Hs
		832672 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2A1J_HUMAN (1-128): 6.6e-68: 202: 95.31
+	Hs
		832496 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2A2C_HUMAN (1-127): 3.2e-67: 200: 96.06
+	Hs
		832683 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2AJ_HUMAN (1-127): 5.24e-67: 200: 95.28
+	Hs
		555351 MCM2_HUMAN (1-904): 0: 1078: 100.00		H2AX_HUMAN (1-123): 4.57e-66: 198: 95.94
+	Hs
		391569 MCM4_HUMAN (2-885): 0: 847: 28.42		H2A1B_HUMAN (1-130): 1e-67: 202: 93.85
+	Hs
		708464 MCM4_HUMAN (2-885): 0: 847: 28.42		H2A2A_HUMAN (1-130): 5.07e-68: 202: 94.62
+	Hs
		555318 MCM4_HUMAN (2-885): 0: 847: 28.42		H2AX_HUMAN (1-123): 4.57e-66: 198: 95.94
+	Sc
		392333 MCM2_YEAST (11-821): 0: 819: 46.70		H2A2_YEAST (16-121): 8.79e-53: 164: 83.96
+	Hs
		391570 MCM5_HUMAN (169-902): 0: 768: 29.43		H2A1B_HUMAN (1-130): 1e-67: 202: 93.85
+	Hs
		470283 MCM5_HUMAN (169-902): 0: 768: 29.43		H2A1_HUMAN (1-130): 8.04e-68: 202: 94.62
+	Hs
		594826 MCM5_HUMAN (169-902): 0: 768: 29.43		H2A1D_HUMAN (1-130): 9.47e-68: 202: 93.85
+	Hs
		555319 MCM5_HUMAN (169-902): 0: 768: 29.43		H2AX_HUMAN (1-123): 4.57e-66: 198: 95.94