HitPredict

Interactor 1: SOX3 (P41225)
Transcription factor SOX-3
Gene: SOX3

Interactor 2: CDN2A (P42771)
Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A)
Gene: CDKN2A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	28205554
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 446 Hs			1 156
+	Hs
		842735 SOX4_HUMAN (106-216): 3.34e-45: 165: 53.72		CDN2A_HUMAN (1-156): 9.11e-52: 163: 100.00
+	Hs
		872895 SOX2_HUMAN (106-446): 5.38e-41: 150: 50.72		ANR26_HUMAN (3-155): 9.54e-35: 129: 18.71
+	Hs
		872755 SOX2_HUMAN (106-446): 5.38e-41: 150: 50.72		EHMT1_HUMAN (15-147): 1.06e-33: 126: 25.00
+	Hs
		1401396 CIC_HUMAN (38-377): 1.67e-36: 145: 20.39		EHMT1_HUMAN (15-147): 1.06e-33: 126: 25.00
+	Hs
		240000 SOX15_HUMAN (124-302): 3.64e-35: 132: 43.02		EHMT1_HUMAN (15-147): 1.06e-33: 126: 25.00
+	Hs
		872638 SOX2_HUMAN (106-446): 5.38e-41: 150: 50.72		EHMT2_HUMAN (59-152): 1.32e-20: 89.2: 27.37
+	Hs
		274116 SOX2_HUMAN (106-446): 5.38e-41: 150: 50.72		ANR17_HUMAN (69-147): 2.29e-19: 85.5: 20.25
+	Hs
		1396284 CIC_HUMAN (38-377): 1.67e-36: 145: 20.39		EHMT2_HUMAN (59-152): 1.32e-20: 89.2: 27.37
+	Hs
		239983 SOX15_HUMAN (124-302): 3.64e-35: 132: 43.02		EHMT2_HUMAN (59-152): 1.32e-20: 89.2: 27.37
+	Hs
		1396306 SOX17_HUMAN (103-410): 6.95e-33: 130: 26.45		EHMT2_HUMAN (59-152): 1.32e-20: 89.2: 27.37
+	Hs
		872878 SOX2_HUMAN (106-446): 5.38e-41: 150: 50.72		KDIS_HUMAN (86-156): 3.21e-12: 65: 19.48
+	Hs
		872827 SOX2_HUMAN (106-446): 5.38e-41: 150: 50.72		RAI14_HUMAN (1-64): 1e-11: 63.4: 21.21
+	Hs
		1030673 BBX_HUMAN (117-377): 2.31e-29: 123: 18.73		ANK2_HUMAN (3-63): 3.65e-14: 70.7: 24.19