HitPredict

Interactor 1: EPHA4 (P54764)
Ephrin type-A receptor 4 (EC 2.7.10.1) (EPH-like kinase 8) (EK8) (hEK8) (Tyrosine-protein kinase TYRO1) (Tyrosine-protein kinase receptor SEK)
Gene: EPHA4

Interactor 2: PTN13 (Q12923)
Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1)
Gene: PTPN13

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~fn3, FERM_M~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 986 Hs			1 2485
+	Hs
		1020163 EPHA7_HUMAN (5-986): 0: 1212: 62.37		PTN13_HUMAN (1-2485): 0: 1895: 100.00
+	Hs
		872431 EPHA5_HUMAN (2-986): 0: 1201: 63.67		PTN13_HUMAN (1-2485): 0: 1895: 100.00
+	Hs
		665393 EPHA3_HUMAN (26-986): 0: 1182: 63.01		PTN13_HUMAN (1-2485): 0: 1895: 100.00
+	Hs
		665589 EPHB2_HUMAN (30-983): 0: 1169: 58.47		PTN13_HUMAN (1-2485): 0: 1895: 100.00
+	Hs
		665228 EPHA2_HUMAN (27-986): 0: 1059: 50.36		PTN13_HUMAN (1-2485): 0: 1895: 100.00
+	Hs
		600564 EPHA1_HUMAN (17-973): 0: 970: 43.87		PTN13_HUMAN (1-2485): 0: 1895: 100.00
+	Hs
		872635 EPHA4_HUMAN (1-986): 0: 1293: 100.00		PTN11_HUMAN (2083-2480): 4.2e-117: 387: 31.47
+	Hs
		985961 EPHA7_HUMAN (5-986): 0: 1212: 62.37		PTN11_HUMAN (2083-2480): 4.2e-117: 387: 31.47
+	Hs
		872429 EPHA5_HUMAN (2-986): 0: 1201: 63.67		PTN11_HUMAN (2083-2480): 4.2e-117: 387: 31.47
+	Hs
		719689 EPHA5_HUMAN (2-986): 0: 1201: 63.67		RADI_HUMAN (574-969): 6.68e-116: 383: 26.94
+	Hs
		665554 EPHB2_HUMAN (30-983): 0: 1169: 58.47		MERL_HUMAN (558-1049): 1.41e-117: 388: 23.65
+	Hs
		665555 EPHB2_HUMAN (30-983): 0: 1169: 58.47		RADI_HUMAN (574-969): 6.68e-116: 383: 26.94
+	Hs
		665158 EPHA2_HUMAN (27-986): 0: 1059: 50.36		MERL_HUMAN (558-1049): 1.41e-117: 388: 23.65
+	Hs
		665220 EPHA2_HUMAN (27-986): 0: 1059: 50.36		PTN11_HUMAN (2083-2480): 4.2e-117: 387: 31.47
+	Hs
		616944 EPHA8_HUMAN (30-981): 0: 1107: 57.11		PTPRD_HUMAN (2189-2468): 1.65e-92: 337: 30.72
+	Hs
		573629 EPHA5_HUMAN (2-986): 0: 1201: 63.67		PTN1_HUMAN (2229-2465): 2.56e-45: 172: 37.40
+	Hs
		872669 EPHA4_HUMAN (1-986): 0: 1293: 100.00		MAGI2_HUMAN (873-1270): 1.19e-11: 72.9: 16.50
+	Hs
		600558 EPHA1_HUMAN (17-973): 0: 970: 43.87		PTN11_HUMAN (2083-2480): 4.2e-117: 387: 31.47
+	Hs
		573583 EPHA8_HUMAN (30-981): 0: 1107: 57.11		PTN1_HUMAN (2229-2465): 2.56e-45: 172: 37.40
+	Hs
		411278 INSR_HUMAN (284-902): 1.29e-145: 470: 25.00		PTPRC_HUMAN (2155-2465): 8.58e-71: 265: 24.78