HitPredict

Interactor 1: CLK2 (P49760)
Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2)
Gene: CLK2

Interactor 2: LARP7 (Q4G0J3)
La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S)
Gene: LARP7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 499 Hs			1 582
+	Hs
		834056 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		625477 CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		960098 CDK3_HUMAN (160-495): 1.29e-125: 370: 24.20		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		1116424 DYRK2_HUMAN (9-499): 1.04e-115: 355: 22.20		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		414946 CDK1_HUMAN (160-485): 3.05e-114: 340: 23.95		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		516416 CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00		PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29
+	Hs
		833939 CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00		LAR4B_HUMAN (2-216): 8.48e-36: 145: 17.02
+	Hs
		834033 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		PABP4_HUMAN (1-208): 8.15e-41: 158: 11.98
+	Hs
		516417 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29
+	Hs
		833945 CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00		PABP5_HUMAN (12-206): 7.64e-32: 128: 14.15
+	Hs
		834088 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		LAR4B_HUMAN (2-216): 8.48e-36: 145: 17.02
+	Hs
		403088 CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70		LA_HUMAN (24-365): 5.96e-44: 163: 18.83
+	Hs
		516362 CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70		PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29
+	Hs
		834096 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		PABP5_HUMAN (12-206): 7.64e-32: 128: 14.15
+	Hs
		1174827 DYRK2_HUMAN (9-499): 1.04e-115: 355: 22.20		LARP4_HUMAN (22-216): 3.23e-40: 157: 21.32
+	Hs
		833905 CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00		LARP1_HUMAN (29-114): 6.35e-13: 73.8: 40.23
+	Hs
		516508 DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50		PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29
+	Hs
		834068 CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32		LARP1_HUMAN (29-114): 6.35e-13: 73.8: 40.23
+	Hs
		1162628 DYRK2_HUMAN (9-499): 1.04e-115: 355: 22.20		LARP1_HUMAN (29-114): 6.35e-13: 73.8: 40.23
+	Hs
		414931 CDK1_HUMAN (160-485): 3.05e-114: 340: 23.95		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50