HitPredict

Interactor 1: CLK3 (P49761)
Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3)
Gene: CLK3

Interactor 2: PABP5 (Q96DU9)
Polyadenylate-binding protein 5 (PABP-5) (Poly(A)-binding protein 5)
Gene: PABPC5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 638 Hs			1 382
+	Hs
		833945 CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52		PABP5_HUMAN (1-382): 2.22e-103: 311: 100.00
+	Hs
		834033 CLK3_HUMAN (1-638): 0: 542: 100.00		PABP4_HUMAN (5-199): 1.19e-17: 86.6: 15.74
+	Hs
		516417 CLK3_HUMAN (1-638): 0: 542: 100.00		PABP1_HUMAN (292-378): 3.47e-17: 85.1: 23.60
+	At
		621700 CDKA1_ARATH (301-623): 2.57e-123: 368: 23.33		RB45A_ARATH (189-379): 2.8e-40: 148: 21.32
+	Hs
		582139 CLK1_HUMAN (149-625): 1.2e-137: 412: 48.67		NUCL_HUMAN (4-96): 1.1e-19: 92.8: 30.11
+	Hs
		516362 CDK2_HUMAN (301-631): 4.28e-138: 406: 24.26		PABP1_HUMAN (292-378): 3.47e-17: 85.1: 23.60
+	Hs
		516416 CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52		PABP1_HUMAN (292-378): 3.47e-17: 85.1: 23.60
+	Hs
		582281 DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20		NUCL_HUMAN (4-96): 1.1e-19: 92.8: 30.11
+	Hs
		642764 DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20		ELAV4_HUMAN (274-378): 1.03e-18: 88.5: 18.69
+	Hs
		1031320 DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20		PABP4_HUMAN (5-199): 1.19e-17: 86.6: 15.74
+	Hs
		516508 DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20		PABP1_HUMAN (292-378): 3.47e-17: 85.1: 23.60
+	Hs
		414728 CDK1_HUMAN (301-624): 5.68e-119: 357: 24.70		NUCL_HUMAN (4-96): 1.1e-19: 92.8: 30.11