Protein: GCN2
eIF-2-alpha kinase GCN2 (EC 2.7.11.1) (General control non-derepressible protein 2) (Serine/threonine-protein kinase GCN2)

Gene: GCN2
Organism: Saccharomyces cerevisiae S288C
Interactions: 90
UniProt ID: P15442

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0000077 - DNA damage checkpoint signaling
GO:0003725 - double-stranded RNA binding
GO:0004672 - protein kinase activity
GO:0004694 - eukaryotic translation initiation factor 2alpha kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

584331

GCN2
eIF-2-alpha kinase GCN2

7

18

Small-scale

0.972

High

584349

HRR25
Casein kinase I homolog HRR25

3

14

Small-scale

0.871

High

392154

HSP82
ATP-dependent molecular chaperone HSP82

3

20

Small-scale

0.856

High

584369

GCN20
Protein GCN20

2

1

Small-scale

0.812

High

584341

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

2

10

Small-scale

0.778

High

584386

PKH1
Serine/threonine-protein kinase PKH1

1

18

Small-scale

0.747

High

584356

GCN1
eIF-2-alpha kinase activator GCN1

5

8

Small-scale

0.720

High

560643

KIN2
Serine/threonine-protein kinase KIN2

1

16

High-throughput

0.691

High

584343

NPR1
Nitrogen permease reactivator protein

1

20

High-throughput

0.691

High

584377

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

4

High-throughput

0.691

High

394187

EF1A
Elongation factor 1-alpha

4

2

Small-scale

0.689

High

584358

HSL1
Probable serine/threonine-protein kinase HSL1

1

18

High-throughput

0.665

High

584398

YRA1
RNA annealing protein YRA1

1

4

High-throughput

0.665

High

584380

EIF2A
Eukaryotic translation initiation factor 2A

3

5

Small-scale

0.655

High

548877

SCH9
Serine/threonine-protein kinase SCH9

1

19

Small-scale

0.647

High

584387

SKY1
Serine/threonine-protein kinase SKY1

1

17

High-throughput

0.647

High

584338

PRP6
Pre-mRNA-splicing factor 6

2

4

High-throughput

0.621

High

584339

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

2

3

High-throughput

0.621

High

584360

SN114
Pre-mRNA-splicing factor SNU114

2

6

High-throughput

0.621

High

584393

RGC1
Regulator of the glycerol channel 1

2

2

High-throughput

0.619

High

448628

SNF1
Carbon catabolite-derepressing protein kinase

1

15

Small-scale

0.618

High

584379

UBC9
SUMO-conjugating enzyme UBC9

1

6

High-throughput

0.618

High

584382

APJ1
J domain-containing protein APJ1

1

6

High-throughput

0.618

High

584351

AAR2
A1 cistron-splicing factor AAR2

2

0

High-throughput

0.595

High

584378

PRP31
Pre-mRNA-processing factor 31

2

0

High-throughput

0.595

High

584400

SNU66
66 kDa U4/U6.U5 small nuclear ribonucleoprotein component

2

0

High-throughput

0.595

High

584392

UTP21
U3 small nucleolar RNA-associated protein 21

2

1

High-throughput

0.588

High

584362

KOG1
Target of rapamycin complex 1 subunit KOG1

1

4

Small-scale

0.578

High

525827

HSP72
Heat shock protein SSA2

2

17

High-throughput

0.552

High

584350

XPO1
Exportin-1

1

9

High-throughput

0.536

High

584354

BRR2
Pre-mRNA-splicing helicase BRR2

1

3

High-throughput

0.536

High

584355

PRP8
Pre-mRNA-splicing factor 8

1

2

High-throughput

0.536

High

584375

YMR1
Phosphoinositide 3-phosphatase

1

2

High-throughput

0.536

High

547752

NHP6A
Non-histone chromosomal protein 6A

1

7

High-throughput

0.515

High

575565

PP2B2
Serine/threonine-protein phosphatase 2B catalytic subunit A2

1

9

High-throughput

0.515

High

584347

SPT5
Transcription elongation factor SPT5

1

2

High-throughput

0.515

High

584364

STM1
Suppressor protein STM1

1

1

High-throughput

0.515

High

584381

BRE5
UBP3-associated protein BRE5

1

4

High-throughput

0.515

High

584383

SLM2
Phosphatidylinositol 4,5-bisphosphate-binding protein SLM2

1

2

High-throughput

0.515

High

584388

HMO1
High mobility group protein 1

1

4

High-throughput

0.515

High

577023

SEC63
Protein translocation protein SEC63

1

9

High-throughput

0.514

High

584368

RRG9
Required for respiratory growth protein 9, mitochondrial

1

0

High-throughput

0.513

High

454553

TFS2
Transcription elongation factor S-II

1

1

High-throughput

0.501

High

502815

RS22A
Small ribosomal subunit protein uS8A

1

2

Small-scale

0.501

High

584336

RDS2
Regulator of drug sensitivity 2

1

2

High-throughput

0.501

High

584340

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

1

High-throughput

0.501

High

584357

YBF5
Deoxyribonuclease Tat-D

1

1

High-throughput

0.501

High

584401

RS22B
Small ribosomal subunit protein uS8B

1

2

Small-scale

0.501

High

584333

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

2

High-throughput

0.500

High

584345

CDC48
Cell division control protein 48

1

3

High-throughput

0.500

High

584390

SAS4
Something about silencing protein 4

1

0

High-throughput

0.493

High

584391

GFD1
mRNA transport factor GFD1

1

0

High-throughput

0.493

High

584371

NMD5
Nonsense-mediated mRNA decay protein 5

1

5

Small-scale

0.481

High

414987

RL39
Large ribosomal subunit protein eL39

1

0

Small-scale

0.480

High

478582

IF2B
Eukaryotic translation initiation factor 2 subunit beta

1

0

Small-scale

0.480

High

584384

2ABA
Protein phosphatase PP2A regulatory subunit B

1

0

High-throughput

0.480

High

584385

NAA35
N-alpha-acetyltransferase 35, NatC auxiliary subunit

1

0

High-throughput

0.480

High

584396

NOB1
20S-pre-rRNA D-site endonuclease NOB1

1

0

High-throughput

0.480

High

584337

PMA2
Plasma membrane ATPase 2

1

3

High-throughput

0.479

High

584342

XRN1
5'-3' exoribonuclease 1

1

1

Small-scale

0.479

High

584346

RL16A
Large ribosomal subunit protein uL13A

1

1

High-throughput

0.479

High

584348

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

584359

TOR1
Serine/threonine-protein kinase TOR1

1

10

Small-scale

0.479

High

584376

IML1
Vacuolar membrane-associated protein IML1

1

2

High-throughput

0.479

High

584389

SCC2
Sister chromatid cohesion protein 2

1

2

High-throughput

0.479

High

584397

RRP6
Exosome complex exonuclease RRP6

1

2

High-throughput

0.479

High

584399

SIZ2
E3 SUMO-protein ligase SIZ2

1

1

High-throughput

0.479

High

584335

CLC1
Clathrin light chain

1

2

High-throughput

0.470

High

395218

GCN4
General control transcription factor GCN4

1

0

Small-scale

0.460

High

584374

DPOD3
DNA polymerase delta subunit 3

1

0

Small-scale

0.460

High

584334

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.458

High

584394

HBT1
Protein HBT1

1

0

High-throughput

0.458

High

584370

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

1

9

High-throughput

0.457

High

584361

ANM1
Protein arginine N-methyltransferase 1

1

5

High-throughput

0.457

High

453400

PYR1
Multifunctional protein URA2

1

6

High-throughput

0.445

High

481461

HSP73
Heat shock protein SSA3

1

17

High-throughput

0.445

High

522940

HSP71
Heat shock protein SSA1

1

17

High-throughput

0.445

High

543693

SSB1
Ribosome-associated molecular chaperone SSB1

1

17

High-throughput

0.445

High

584332

VATB
V-type proton ATPase subunit B

1

7

High-throughput

0.445

High

584352

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

584353

HSP79
Heat shock protein homolog SSE2

1

20

High-throughput

0.445

High

584365

TCPD
T-complex protein 1 subunit delta

1

2

High-throughput

0.445

High

584366

HSP7E
Heat shock protein SSC3, mitochondrial

1

18

High-throughput

0.445

High

584367

SSB2
Ribosome-associated molecular chaperone SSB2

1

17

High-throughput

0.445

High

584372

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.445

High

584373

TCPQ
T-complex protein 1 subunit theta

1

1

High-throughput

0.445

High

584363

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

1

Small-scale

0.437

High

584344

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.426

High

584395

SPO75
Sporulation-specific protein 75

1

0

High-throughput

0.269

Low


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Last updated: 11Aug2025