HitPredict

Interactor 1: CASP3 (P42574)
Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
Gene: CASP3

Interactor 2: GRAM (P51124)
Granzyme M (EC 3.4.21.-) (Met-1 serine protease) (Hu-Met-1) (Met-ase) (Natural killer cell granular protease)
Gene: GZMM

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	16818775
Identification Methods	protease assay
Interaction Type	protein cleavage

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006508 - proteolysis GO:0006915 - apoptotic process GO:0051604 - protein maturation
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 277 Hs			1 257
+	Hs
		518734 CASP3_HUMAN (1-277): 2.24e-146: 412: 100.00		GRAB_HUMAN (25-255): 4.26e-39: 137: 36.82
+	Hs
		634747 CASP3_HUMAN (1-277): 2.24e-146: 412: 100.00		GRAH_HUMAN (25-255): 9.52e-38: 134: 38.24
+	Mm
		405586 CASP3_MOUSE (1-277): 1.35e-141: 400: 86.64		GRAB_MOUSE (25-256): 1.22e-39: 139: 37.40
+	Hs
		628393 CASP3_HUMAN (1-277): 2.24e-146: 412: 100.00		KLK2_HUMAN (9-250): 2.32e-31: 118: 35.25
+	Mm
		405587 CASP7_MOUSE (37-275): 4.82e-115: 334: 59.50		GRAB_MOUSE (25-256): 1.22e-39: 139: 37.40
+	Hs
		518738 CASP7_HUMAN (2-275): 1.79e-114: 333: 50.35		GRAB_HUMAN (25-255): 4.26e-39: 137: 36.82
+	Hs
		518739 CASP9_HUMAN (34-275): 1.59e-95: 288: 33.21		GRAB_HUMAN (25-255): 4.26e-39: 137: 36.82
+	Hs
		518746 CASP8_HUMAN (25-275): 8.16e-93: 283: 35.32		GRAB_HUMAN (25-255): 4.26e-39: 137: 36.82
+	Hs
		1132470 CASP8_HUMAN (25-275): 8.16e-93: 283: 35.32		KLK5_HUMAN (24-251): 3.46e-31: 118: 33.33
+	Hs
		518732 CASP1_HUMAN (2-276): 3.38e-78: 244: 26.26		GRAB_HUMAN (25-255): 4.26e-39: 137: 36.82
+	Hs
		518749 CASPA_HUMAN (36-230): 3e-72: 232: 34.65		GRAB_HUMAN (25-255): 4.26e-39: 137: 36.82