HitPredict

Interactor 1: R144A (P50876)
E3 ubiquitin-protein ligase RNF144A (EC 2.3.2.31) (RING finger protein 144A) (UbcM4-interacting protein 4) (Ubiquitin-conjugating enzyme 7-interacting protein 4)
Gene: RNF144A

Interactor 2: UB2G1 (P62253)
Ubiquitin-conjugating enzyme E2 G1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme G1) (E217K) (UBC7) (Ubiquitin carrier protein G1) (Ubiquitin-protein ligase G1) [Cleaved into: Ubiquitin-conjugating enzyme E2 G1, N-terminally processed]
Gene: UBE2G1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	IBR~UQ_con
Common GO terms	GO:0000209 - protein polyubiquitination GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 292 Hs			1 170
+	Hs
		842095 R144A_HUMAN (1-292): 5.59e-97: 288: 100.00		UB2D1_HUMAN (5-165): 3.89e-71: 212: 34.78
+	Hs
		842104 R144A_HUMAN (1-292): 5.59e-97: 288: 100.00		UB2D2_HUMAN (5-165): 1.03e-70: 212: 32.92
+	Hs
		919876 RN19A_HUMAN (16-276): 5.96e-75: 246: 25.00		UB2D2_HUMAN (5-165): 1.03e-70: 212: 32.92
+	Hs
		919757 RN19B_HUMAN (13-276): 3.98e-73: 240: 25.54		UB2D2_HUMAN (5-165): 1.03e-70: 212: 32.92
+	Hs
		895819 RN19B_HUMAN (13-276): 3.98e-73: 240: 25.54		UB2D3_HUMAN (5-165): 3.29e-69: 208: 32.92
+	Hs
		908261 CUL9_HUMAN (9-223): 4.72e-62: 214: 24.78		UB2G1_HUMAN (1-170): 2.18e-78: 232: 100.00
+	Hs
		312622 ARI2_HUMAN (2-231): 1.5e-64: 211: 25.53		UB2R2_HUMAN (1-163): 6.15e-72: 218: 54.27
+	Hs
		849498 ARI1_HUMAN (14-229): 1.58e-64: 213: 27.35		UB2D1_HUMAN (5-165): 3.89e-71: 212: 34.78
+	Hs
		312679 ARI2_HUMAN (2-231): 1.5e-64: 211: 25.53		UB2D4_HUMAN (5-165): 1.53e-71: 213: 34.16
+	Hs
		312520 ARI2_HUMAN (2-231): 1.5e-64: 211: 25.53		UB2D1_HUMAN (5-165): 3.89e-71: 212: 34.78
+	Hs
		312553 ARI2_HUMAN (2-231): 1.5e-64: 211: 25.53		UB2D2_HUMAN (5-165): 1.03e-70: 212: 32.92
+	Hs
		895968 ARI1_HUMAN (14-229): 1.58e-64: 213: 27.35		UB2D3_HUMAN (5-165): 3.29e-69: 208: 32.92
+	Hs
		312528 ARI2_HUMAN (2-231): 1.5e-64: 211: 25.53		UB2D3_HUMAN (5-165): 3.29e-69: 208: 32.92
+	Hs
		1354303 RNF14_HUMAN (14-239): 1.82e-59: 198: 22.93		UB2D4_HUMAN (5-165): 1.53e-71: 213: 34.16
+	Hs
		849474 RNF14_HUMAN (14-239): 1.82e-59: 198: 22.93		UB2D1_HUMAN (5-165): 3.89e-71: 212: 34.78
+	Hs
		919891 RNF14_HUMAN (14-239): 1.82e-59: 198: 22.93		UB2D2_HUMAN (5-165): 1.03e-70: 212: 32.92
+	Hs
		895938 RNF14_HUMAN (14-239): 1.82e-59: 198: 22.93		UB2D3_HUMAN (5-165): 3.29e-69: 208: 32.92
+	Dm
		639397 LUBEL_DROME (19-225): 2.33e-55: 194: 22.22		UBCD1_DROME (5-165): 3.52e-70: 210: 34.16
+	Sc
		549808 HEL1_YEAST (11-221): 5.64e-54: 185: 21.56		UBC4_YEAST (4-165): 4.48e-70: 210: 33.33
+	Hs
		828005 RNF31_HUMAN (19-218): 8.15e-50: 178: 23.04		UB2R1_HUMAN (1-163): 6.6e-70: 213: 51.83