HitPredict

Interactor 1: SCNNB (P51168)
Amiloride-sensitive sodium channel subunit beta (Beta-NaCH) (Epithelial Na(+) channel subunit beta) (Beta-ENaC) (ENaCB) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB)
Gene: SCNN1B

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	11244092
Identification Methods	far western blotting
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 640 Hs			1 903
+	Hs
		125256 SCNNB_HUMAN (1-640): 0: 701: 100.00		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		739603 SCNNA_HUMAN (21-627): 0: 558: 31.54		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		845978 SCNNB_HUMAN (1-640): 0: 701: 100.00		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Mm
		1208291 SCNNB_MOUSE (1-640): 0: 664: 83.91		NED4L_MOUSE (2-900): 0: 765: 32.32
+	Rn
		739630 SCNNG_RAT (16-625): 0: 586: 36.16		Q4V8H7_RAT (1-903): 0: 837: 57.04
+	Hs
		125257 SCNNG_HUMAN (17-626): 0: 580: 36.22		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		125197 SCNNA_HUMAN (21-627): 0: 558: 31.54		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		808049 SCNNB_HUMAN (1-640): 0: 701: 100.00		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		845991 SCNNG_HUMAN (17-626): 0: 580: 36.22		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Mm
		93285 SCNNB_MOUSE (1-640): 0: 664: 83.91		E9PXB7_MOUSE (86-900): 0: 654: 34.22
+	Hs
		808050 SCNNG_HUMAN (17-626): 0: 580: 36.22		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Mm
		93286 SCNNG_MOUSE (16-625): 0: 587: 36.19		E9PXB7_MOUSE (86-900): 0: 654: 34.22
+	Hs
		739582 SCNNA_HUMAN (21-627): 0: 558: 31.54		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		739597 SCNNA_HUMAN (21-627): 0: 558: 31.54		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88
+	Rn
		739628 SCNNB_RAT (1-640): 0: 683: 83.44		NEDD4_RAT (7-426): 3.03e-54: 205: 18.07
+	Mm
		808382 SCNNB_MOUSE (1-640): 0: 664: 83.91		NEDD4_MOUSE (13-426): 2.27e-52: 199: 18.38
+	Rn
		739631 SCNNG_RAT (16-625): 0: 586: 36.16		NEDD4_RAT (7-426): 3.03e-54: 205: 18.07
+	Mm
		808383 SCNNG_MOUSE (16-625): 0: 587: 36.19		NEDD4_MOUSE (13-426): 2.27e-52: 199: 18.38
+	Hs
		845975 SCNNB_HUMAN (1-640): 0: 701: 100.00		HECW1_HUMAN (26-479): 2.25e-13: 76.9: 10.76
+	Hs
		739596 SCNNA_HUMAN (21-627): 0: 558: 31.54		HECW1_HUMAN (26-479): 2.25e-13: 76.9: 10.76