Protein: KSYK
Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase)

Gene: KSYK, Syk
Organism: Mus musculus
Interactions: 39
UniProt ID: P48025

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001775 - cell activation
GO:0001784 - phosphotyrosine residue binding
GO:0001819 - positive regulation of cytokine production
GO:0001820 - serotonin secretion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

838264

STAT3
Signal transducer and activator of transcription 3

1

20

Small-scale

0.757

High

869546

CLC7A
C-type lectin domain family 7 member A

5

14

Small-scale

0.702

High

869539

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.691

High

431332

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.618

High

683089

LYN
Tyrosine-protein kinase Lyn

1

20

Small-scale

0.618

High

711217

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

20

Small-scale

0.618

High

869538

DOK1
Docking protein 1

1

20

Small-scale

0.618

High

869544

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

20

Small-scale

0.618

High

869550

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

20

Small-scale

0.618

High

869556

TLR4
Toll-like receptor 4

1

20

Small-scale

0.618

High

869557

TBK1
Serine/threonine-protein kinase TBK1

1

20

Small-scale

0.618

High

869541

Q5U3L0
SH3 domain-binding protein 2

1

11

Small-scale

0.579

High

571267

FGR
Tyrosine-protein kinase Fgr

1

19

Small-scale

0.575

High

869535

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.575

High

770693

CD22
B-cell receptor CD22

1

20

Small-scale

0.561

High

869545

OBF1
POU domain class 2-associating factor 1

1

0

Small-scale

0.537

High

648036

MYD88
Myeloid differentiation primary response protein MyD88

1

20

Small-scale

0.536

High

869536

TBA4A
Tubulin alpha-4A chain

1

20

Small-scale

0.536

High

869547

TCAM1
TIR domain-containing adapter molecule 1

1

20

Small-scale

0.536

High

236565

ITB3
Integrin beta-3

1

20

Small-scale

0.479

High

633285

FCERG
High affinity immunoglobulin epsilon receptor subunit gamma

1

7

Small-scale

0.479

High

651497

CBL
E3 ubiquitin-protein ligase CBL

1

20

Small-scale

0.479

High

669408

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

20

Small-scale

0.479

High

712507

CASP1
Caspase-1

1

7

Small-scale

0.479

High

869537

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.479

High

869540

CBLB
E3 ubiquitin-protein ligase CBL-B

1

20

Small-scale

0.479

High

869542

TRAF3
TNF receptor-associated factor 3

1

20

Small-scale

0.479

High

869548

FACD2
Fanconi anemia group D2 protein homolog

1

10

High-throughput

0.479

High

869549

A16L1
Autophagy-related protein 16-1

1

20

High-throughput

0.479

High

869552

TRI31
E3 ubiquitin-protein ligase TRIM31

1

16

Small-scale

0.479

High

869554

NFAM1
NFAT activation molecule 1

1

1

Small-scale

0.479

High

869558

CLC4D
C-type lectin domain family 4 member D

1

12

Small-scale

0.479

High

869543

I15RA
Interleukin-15 receptor subunit alpha

1

0

Small-scale

0.458

High

419943

B3AT
Band 3 anion transport protein

1

14

Small-scale

0.457

High

450386

CSF1
Macrophage colony-stimulating factor 1

1

15

Small-scale

0.445

High

869553

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

5

Small-scale

0.445

High

869555

ASC
Apoptosis-associated speck-like protein containing a CARD

1

6

Small-scale

0.445

High

869551

WIPF1
WAS/WASL-interacting protein family member 1

1

20

Small-scale

0.437

High


Service provided by Combinatics, Japan

Last updated: 11Aug2025