HitPredict

Interactor 1: PPP5 (P53041)
Serine/threonine-protein phosphatase 5 (PP5) (EC 3.1.3.16) (Protein phosphatase T) (PP-T) (PPT)
Gene: PPP5C

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	14764652
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 499 Hs			1 530
+	Hs
		369237 PPP5_HUMAN (1-499): 0: 575: 100.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		915249 PP2AB_HUMAN (182-485): 6.26e-163: 465: 38.69		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		377203 PPP5_HUMAN (1-499): 0: 575: 100.00		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		737951 PP1G_HUMAN (196-488): 1.79e-154: 444: 36.88		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		906550 PP1B_HUMAN (203-490): 1.32e-154: 444: 36.09		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		906054 PP1A_HUMAN (200-479): 5.19e-154: 443: 38.79		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369364 PP2AA_HUMAN (190-481): 5.28e-167: 475: 40.88		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369332 PP2AB_HUMAN (182-485): 6.26e-163: 465: 38.69		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369103 PP1G_HUMAN (196-488): 1.79e-154: 444: 36.88		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369309 PP1A_HUMAN (200-479): 5.19e-154: 443: 38.79		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Mm
		587097 PP1G_MOUSE (196-488): 1.32e-154: 444: 36.88		ESR1_MOUSE (9-529): 4.88e-134: 403: 43.72
+	Hs
		320201 PP2AA_HUMAN (190-481): 5.28e-167: 475: 40.88		ERR2_HUMAN (69-499): 5.86e-109: 333: 31.57
+	Hs
		320195 PP2AB_HUMAN (182-485): 6.26e-163: 465: 38.69		ERR2_HUMAN (69-499): 5.86e-109: 333: 31.57
+	Hs
		414470 PPP5_HUMAN (1-499): 0: 575: 100.00		PRGR_HUMAN (149-459): 2.26e-41: 161: 32.82
+	Hs
		437629 PPP5_HUMAN (1-499): 0: 575: 100.00		MCR_HUMAN (141-408): 5.92e-38: 150: 34.03
+	Hs
		487258 PPP5_HUMAN (1-499): 0: 575: 100.00		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		487319 PP2AA_HUMAN (190-481): 5.28e-167: 475: 40.88		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		487291 PP1B_HUMAN (203-490): 1.32e-154: 444: 36.09		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		437630 PP1A_HUMAN (200-479): 5.19e-154: 443: 38.79		MCR_HUMAN (141-408): 5.92e-38: 150: 34.03
+	Hs
		487290 PP1A_HUMAN (200-479): 5.19e-154: 443: 38.79		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59