HitPredict

Interactor 1: DAPK1 (P53355)
Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1)
Gene: DAPK1

Interactor 2: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~EF-hand_7, Ank_2~SH3_1, EF-hand_7~Pkinase
Common GO terms	GO:0005516 - calmodulin binding GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1430 Hs			1 2472
+	Hs
		164586 DAPK1_HUMAN (1-1430): 0: 1999: 100.00		SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41
+	Hs
		862027 DAPK1_HUMAN (1-1430): 0: 1999: 100.00		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		521508 DAPK1_HUMAN (1-1430): 0: 1999: 100.00		ACTN1_HUMAN (1862-2210): 3.16e-11: 71.2: 22.25
+	Hs
		862098 DAPK1_HUMAN (1-1430): 0: 1999: 100.00		CP250_HUMAN (1768-2439): 4.39e-10: 67.7: 8.94
+	Hs
		211541 DAPK1_HUMAN (1-1430): 0: 1999: 100.00		ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15
+	Hs
		965102 ANK2_HUMAN (248-797): 3.54e-109: 385: 19.42		SPTN1_HUMAN (1-2472): 0: 714: 100.00
+	Mm
		561172 ANK2_MOUSE (408-943): 6.8e-107: 378: 18.87		SPTN1_MOUSE (1-2472): 0: 712: 98.42
+	Mm
		82740 ANK3_MOUSE (518-936): 2.88e-74: 276: 16.06		B9EKJ1_MOUSE (1-2472): 0: 706: 98.18
+	Hs
		360612 ANK1_HUMAN (503-915): 9.04e-72: 267: 15.66		SPTA1_HUMAN (1-2472): 2.98e-159: 552: 54.81
+	Hs
		164604 ANK2_HUMAN (248-797): 3.54e-109: 385: 19.42		SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41
+	Hs
		963292 ANK2_HUMAN (248-797): 3.54e-109: 385: 19.42		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		965174 ANK2_HUMAN (248-797): 3.54e-109: 385: 19.42		MACF1_HUMAN (9-1261): 9.1e-18: 93.6: 12.48
+	Mm
		515254 KCC2A_MOUSE (1-383): 5.07e-120: 385: 29.17		ACTN2_MOUSE (1843-2210): 5.15e-13: 77: 23.23
+	Mm
		103598 ANK3_MOUSE (518-936): 2.88e-74: 276: 16.06		Q3UGX2_MOUSE (2-1625): 2.78e-45: 183: 19.60
+	Rn
		88556 KCC2A_RAT (1-383): 5.07e-120: 385: 29.17		D3ZCV0_RAT (1843-2210): 4.24e-12: 73.9: 23.43
+	Rn
		506781 KCC2A_RAT (1-383): 5.07e-120: 385: 29.17		ACTN1_RAT (1862-2210): 1.85e-11: 72: 22.51
+	Hs
		521641 KCC2A_HUMAN (1-383): 6.29e-120: 385: 29.17		ACTN1_HUMAN (1862-2210): 3.16e-11: 71.2: 22.25
+	Hs
		211695 KCC2A_HUMAN (1-383): 6.29e-120: 385: 29.17		ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15
+	Rn
		251022 ANK3_RAT (518-936): 2.37e-74: 276: 16.00		PLEC_RAT (1-1257): 6.84e-37: 156: 10.91
+	Mm
		103603 ANK3_MOUSE (518-936): 2.88e-74: 276: 16.06		SPTB2_MOUSE (1408-2420): 1.22e-29: 132: 18.86