HitPredict

Interactor 1: ACLY (P53396)
ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (ACL) (Citrate cleavage enzyme)
Gene: ACLY

Interactor 2: ACLY (P53396)
ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (ACL) (Citrate cleavage enzyme)
Gene: ACLY

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.75 1.00 0.868

The method score is based on:

Property Details
Experiments 37071682, 30944472, 30944476, 31873304
Identification Methods cross-linking study, 3D electron microscopy, x-ray crystallography, electron microscopy 3D single particle reconstruction
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Citrate_bind~Citrate_synt, Citrate_bind~CoA_binding, Citrate_bind~Ligase_CoA, Citrate_synt~Citrate_synt, Citrate_synt~CoA_binding, Citrate_synt~Ligase_CoA, CoA_binding~CoA_binding, CoA_binding~Ligase_CoA, Ligase_CoA~Ligase_CoA
Common GO terms GO:0003878 - ATP citrate synthase activity
GO:0005524 - ATP binding
GO:0005576 - extracellular region
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
and 13 others

more...
Homologous interactions 7

Homologous interactions

Color coding for hit scores

1 1101
Hs

1 1101
+ Dm
+ Hs
+ Ss
+ Hs
+ Ec
+ Sc
+ Sc

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024