HitPredict

Interactor 1: RHO1 (P48148)
Ras-like GTP-binding protein Rho1
Gene: RHO1

Interactor 2: Q9VW59 (Q9VW59)
Rho GDP-dissociation inhibitor 3 (Rho-GDI gamma)
Gene: RhoGDI

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	22036573, 38944040
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ras~Rho_GDI
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Dm			1 201
+	Hs
		912546 RAC1_HUMAN (1-192): 4.1e-79: 235: 57.73		GDIR1_HUMAN (2-200): 1.73e-99: 288: 48.24
+	Mm
		988911 RAC1_MOUSE (1-192): 4.1e-79: 235: 57.73		GDIR1_MOUSE (2-200): 5.41e-99: 287: 46.73
+	Rn
		962876 RHOA_RAT (1-192): 1.01e-77: 232: 86.53		GDIR1_RAT (2-200): 5.41e-99: 287: 46.73
+	Hs
		912539 RHOA_HUMAN (1-192): 3.89e-77: 230: 86.53		GDIR1_HUMAN (2-200): 1.73e-99: 288: 48.24
+	Hs
		912548 RHOG_HUMAN (1-192): 5.58e-77: 230: 55.21		GDIR1_HUMAN (2-200): 1.73e-99: 288: 48.24
+	Hs
		580945 RAC2_HUMAN (1-192): 7.87e-76: 227: 55.16		GDIR1_HUMAN (2-200): 1.73e-99: 288: 48.24
+	Hs
		466166 RHOC_HUMAN (1-192): 6.94e-75: 225: 83.94		GDIR1_HUMAN (2-200): 1.73e-99: 288: 48.24
+	Hs
		912536 CDC42_HUMAN (1-192): 7.74e-75: 225: 53.89		GDIR1_HUMAN (2-200): 1.73e-99: 288: 48.24
+	At
		1182495 RAC3_ARATH (1-182): 1.32e-84: 249: 49.73		GDIR_ARATH (1-200): 8.99e-86: 254: 38.00
+	Hs
		912629 RAC1_HUMAN (1-192): 4.1e-79: 235: 57.73		GDIR2_HUMAN (1-200): 5.48e-90: 263: 45.05
+	Hs
		988652 RAC1_HUMAN (1-192): 4.1e-79: 235: 57.73		GDIR3_HUMAN (1-200): 1.04e-88: 261: 42.50
+	Hs
		912630 RHOG_HUMAN (1-192): 5.58e-77: 230: 55.21		GDIR2_HUMAN (1-200): 5.48e-90: 263: 45.05
+	Hs
		1015716 RHOG_HUMAN (1-192): 5.58e-77: 230: 55.21		GDIR3_HUMAN (1-200): 1.04e-88: 261: 42.50
+	Hs
		962421 RHOA_HUMAN (1-192): 3.89e-77: 230: 86.53		GDIR3_HUMAN (1-200): 1.04e-88: 261: 42.50
+	Hs
		580946 RAC2_HUMAN (1-192): 7.87e-76: 227: 55.16		GDIR2_HUMAN (1-200): 5.48e-90: 263: 45.05
+	Hs
		955520 CDC42_HUMAN (1-192): 7.74e-75: 225: 53.89		GDIR3_HUMAN (1-200): 1.04e-88: 261: 42.50
+	Sc
		448574 RHO1_YEAST (3-184): 2.84e-91: 267: 72.53		GDIR_YEAST (1-198): 8.64e-71: 215: 37.75
+	Ce
		1041911 RAC1_CAEEL (1-192): 1.51e-78: 234: 54.40		GDIR_CAEEL (11-199): 2.81e-74: 223: 43.16
+	Ce
		1169787 RHO1_CAEEL (1-192): 1.41e-75: 226: 85.94		GDIR_CAEEL (11-199): 2.81e-74: 223: 43.16
+	Cl
		47461 RAC1_CANLF (1-192): 4.1e-79: 235: 57.73		A0A8I3N6C6_CANLF (2-200): 6.93e-64: 196: 35.18