HitPredict

Interactor 1: GDIR1 (P52565)
Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha)
Gene: ARHGDIA

Interactor 2: RHOG (P84095)
Rho-related GTP-binding protein RhoG
Gene: RHOG

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.854

Property	Details
Experiments	11368848, 35271311, 33513601
Identification Methods	two hybrid, affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Ras~Rho_GDI
Common GO terms	GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0007266 - Rho protein signal transduction GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 204 Hs			1 191
+	Hs
		912546 GDIR1_HUMAN (1-204): 5.05e-117: 332: 100.00		RAC1_HUMAN (1-191): 1e-80: 239: 71.88
+	Mm
		988911 GDIR1_MOUSE (1-204): 6.29e-117: 332: 97.06		RAC1_MOUSE (1-191): 1e-80: 239: 71.88
+	Rn
		962876 GDIR1_RAT (1-204): 6.29e-117: 332: 97.06		RHOA_RAT (5-191): 6.39e-78: 232: 55.62
+	Hs
		912536 GDIR1_HUMAN (1-204): 5.05e-117: 332: 100.00		CDC42_HUMAN (1-191): 2.01e-77: 231: 60.73
+	Hs
		912539 GDIR1_HUMAN (1-204): 5.05e-117: 332: 100.00		RHOA_HUMAN (5-191): 2.01e-77: 231: 55.62
+	Hs
		580945 GDIR1_HUMAN (1-204): 5.05e-117: 332: 100.00		RAC2_HUMAN (1-191): 3.6e-77: 230: 71.35
+	Hs
		466166 GDIR1_HUMAN (1-204): 5.05e-117: 332: 100.00		RHOC_HUMAN (5-191): 1.31e-75: 226: 56.15
+	Hs
		912535 GDIR1_HUMAN (1-204): 5.05e-117: 332: 100.00		RAC3_HUMAN (1-177): 2.18e-74: 223: 72.88
+	Mm
		953794 GDIR1_MOUSE (1-204): 6.29e-117: 332: 97.06		RAC3_MOUSE (1-177): 2.18e-74: 223: 72.88
+	At
		1182495 GDIR_ARATH (2-202): 4.37e-89: 263: 37.86		RAC3_ARATH (2-180): 1.17e-91: 267: 56.98
+	Hs
		912629 GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53		RAC1_HUMAN (1-191): 1e-80: 239: 71.88
+	Hs
		912630 GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53		RHOG_HUMAN (1-191): 1.42e-80: 239: 100.00
+	Hs
		1015716 GDIR3_HUMAN (15-204): 5.89e-96: 280: 61.05		RHOG_HUMAN (1-191): 1.42e-80: 239: 100.00
+	Hs
		988652 GDIR3_HUMAN (15-204): 5.89e-96: 280: 61.05		RAC1_HUMAN (1-191): 1e-80: 239: 71.88
+	Hs
		580946 GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53		RAC2_HUMAN (1-191): 3.6e-77: 230: 71.35
+	Hs
		955520 GDIR3_HUMAN (15-204): 5.89e-96: 280: 61.05		CDC42_HUMAN (1-191): 2.01e-77: 231: 60.73
+	Hs
		962421 GDIR3_HUMAN (15-204): 5.89e-96: 280: 61.05		RHOA_HUMAN (5-191): 2.01e-77: 231: 55.62
+	Mm
		953791 GDIR2_MOUSE (13-204): 1.26e-98: 285: 68.75		RAC3_MOUSE (1-177): 2.18e-74: 223: 72.88
+	Hs
		912625 GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53		RAC3_HUMAN (1-177): 2.18e-74: 223: 72.88
+	Dm
		870530 Q9VW59_DROME (16-202): 2.39e-83: 247: 50.53		RHO1_DROME (5-191): 8.38e-74: 222: 56.15