HitPredict

Interactor 1: RAC2 (P15153)
Ras-related C3 botulinum toxin substrate 2 (EC 3.6.5.2) (GX) (Small G protein) (p21-Rac2)
Gene: RAC2

Interactor 2: GDIR1 (P52565)
Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha)
Gene: ARHGDIA

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	9490022, 11368848
Identification Methods	biochemical, two hybrid
Interaction Type	association, direct interaction, physical association

Property	Details
Interacting Pfam domains	Ras~Rho_GDI
Common GO terms	GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 204
+	Hs
		912546 RAC1_HUMAN (1-192): 3.43e-86: 253: 92.19		GDIR1_HUMAN (1-204): 5.05e-117: 332: 100.00
+	Mm
		988911 RAC1_MOUSE (1-192): 3.43e-86: 253: 92.19		GDIR1_MOUSE (1-204): 6.29e-117: 332: 97.06
+	Hs
		912535 RAC3_HUMAN (1-191): 4.97e-80: 238: 89.01		GDIR1_HUMAN (1-204): 5.05e-117: 332: 100.00
+	Mm
		953794 RAC3_MOUSE (1-191): 4.97e-80: 238: 89.01		GDIR1_MOUSE (1-204): 6.29e-117: 332: 97.06
+	Hs
		912548 RHOG_HUMAN (1-192): 5.1e-79: 235: 70.83		GDIR1_HUMAN (1-204): 5.05e-117: 332: 100.00
+	Hs
		912536 CDC42_HUMAN (1-192): 1.66e-78: 234: 68.75		GDIR1_HUMAN (1-204): 5.05e-117: 332: 100.00
+	Rn
		962876 RHOA_RAT (5-192): 5.99e-78: 232: 54.26		GDIR1_RAT (1-204): 6.29e-117: 332: 97.06
+	Hs
		912539 RHOA_HUMAN (5-192): 1.59e-77: 231: 54.26		GDIR1_HUMAN (1-204): 5.05e-117: 332: 100.00
+	Hs
		912629 RAC1_HUMAN (1-192): 3.43e-86: 253: 92.19		GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53
+	Hs
		988652 RAC1_HUMAN (1-192): 3.43e-86: 253: 92.19		GDIR3_HUMAN (15-204): 5.89e-96: 280: 61.05
+	Hs
		580946 RAC2_HUMAN (1-192): 1.14e-83: 247: 100.00		GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53
+	Mm
		953791 RAC3_MOUSE (1-191): 4.97e-80: 238: 89.01		GDIR2_MOUSE (13-204): 1.26e-98: 285: 68.75
+	Hs
		912625 RAC3_HUMAN (1-191): 4.97e-80: 238: 89.01		GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53
+	Hs
		912630 RHOG_HUMAN (1-192): 5.1e-79: 235: 70.83		GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53
+	Hs
		1015716 RHOG_HUMAN (1-192): 5.1e-79: 235: 70.83		GDIR3_HUMAN (15-204): 5.89e-96: 280: 61.05
+	Hs
		955520 CDC42_HUMAN (1-192): 1.66e-78: 234: 68.75		GDIR3_HUMAN (15-204): 5.89e-96: 280: 61.05
+	At
		1182536 RAC5_ARATH (4-177): 3.52e-79: 236: 65.52		GDIR_ARATH (2-202): 4.37e-89: 263: 37.86
+	Cl
		47461 RAC1_CANLF (1-192): 3.43e-86: 253: 92.19		A0A8I3N6C6_CANLF (1-204): 3.53e-81: 240: 76.47
+	Ce
		1041911 RAC1_CAEEL (1-192): 2.62e-84: 248: 79.69		GDIR_CAEEL (20-201): 2.65e-75: 226: 38.80
+	Sc
		618367 CDC42_YEAST (1-192): 2.32e-77: 231: 67.19		GDIR_YEAST (19-200): 5.18e-69: 211: 37.90