HitPredict

Interactor 1: RHOC (P08134)
Rho-related GTP-binding protein RhoC (Rho cDNA clone 9) (h9)
Gene: RHOC

Interactor 2: GDIR1 (P52565)
Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha)
Gene: ARHGDIA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.855

Property	Details
Experiments	17353931, 35271311, 36192543
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ras~Rho_GDI
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 204
+	Rn
		962876 RHOA_RAT (1-193): 1.03e-81: 242: 92.23		GDIR1_RAT (1-204): 6.29e-117: 332: 97.06
+	Hs
		912539 RHOA_HUMAN (1-193): 4.28e-81: 240: 91.71		GDIR1_HUMAN (1-204): 5.05e-117: 332: 100.00
+	Hs
		912546 RAC1_HUMAN (1-193): 6.84e-81: 240: 57.22		GDIR1_HUMAN (1-204): 5.05e-117: 332: 100.00
+	Mm
		988911 RAC1_MOUSE (1-193): 6.84e-81: 240: 57.22		GDIR1_MOUSE (1-204): 6.29e-117: 332: 97.06
+	Hs
		912548 RHOG_HUMAN (1-193): 2.26e-78: 233: 54.92		GDIR1_HUMAN (1-204): 5.05e-117: 332: 100.00
+	Hs
		912536 CDC42_HUMAN (1-193): 8.86e-78: 232: 51.30		GDIR1_HUMAN (1-204): 5.05e-117: 332: 100.00
+	Hs
		580945 RAC2_HUMAN (1-193): 2.92e-77: 231: 54.12		GDIR1_HUMAN (1-204): 5.05e-117: 332: 100.00
+	At
		1182495 RAC3_ARATH (2-193): 1.56e-92: 270: 48.99		GDIR_ARATH (2-202): 4.37e-89: 263: 37.86
+	Hs
		912629 RAC1_HUMAN (1-193): 6.84e-81: 240: 57.22		GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53
+	Hs
		962421 RHOA_HUMAN (1-193): 4.28e-81: 240: 91.71		GDIR3_HUMAN (15-204): 5.89e-96: 280: 61.05
+	Hs
		988652 RAC1_HUMAN (1-193): 6.84e-81: 240: 57.22		GDIR3_HUMAN (15-204): 5.89e-96: 280: 61.05
+	Hs
		912630 RHOG_HUMAN (1-193): 2.26e-78: 233: 54.92		GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53
+	Hs
		1015716 RHOG_HUMAN (1-193): 2.26e-78: 233: 54.92		GDIR3_HUMAN (15-204): 5.89e-96: 280: 61.05
+	Hs
		580946 RAC2_HUMAN (1-193): 2.92e-77: 231: 54.12		GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53
+	Hs
		955520 CDC42_HUMAN (1-193): 8.86e-78: 232: 51.30		GDIR3_HUMAN (15-204): 5.89e-96: 280: 61.05
+	Sc
		448574 RHO1_YEAST (3-179): 1.62e-95: 278: 74.01		GDIR_YEAST (19-200): 5.18e-69: 211: 37.90
+	Cl
		47461 RAC1_CANLF (1-193): 6.84e-81: 240: 57.22		A0A8I3N6C6_CANLF (1-204): 3.53e-81: 240: 76.47
+	Dm
		870530 RHO1_DROME (1-193): 9.94e-77: 229: 85.49		Q9VW59_DROME (16-202): 2.39e-83: 247: 50.53
+	Ce
		1041911 RAC1_CAEEL (1-193): 3.47e-81: 240: 53.89		GDIR_CAEEL (20-201): 2.65e-75: 226: 38.80
+	Sc
		618367 CDC42_YEAST (1-193): 7.77e-76: 227: 50.26		GDIR_YEAST (19-200): 5.18e-69: 211: 37.90