HitPredict

Interactor 1: EPHA5 (P54756)
Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (EPH homology kinase 1) (EHK-1) (EPH-like kinase 7) (EK7) (hEK7)
Gene: EPHA5

Interactor 2: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1037 Hs			1 378
+	Hs
		665401 EPHA3_HUMAN (51-1037): 0: 1232: 66.53		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		872655 EPHA4_HUMAN (33-1035): 0: 1223: 62.04		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		1072507 EPHA7_HUMAN (37-1035): 0: 1222: 62.69		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		665610 EPHB2_HUMAN (60-1034): 0: 1209: 56.80		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		1083031 EPHA6_HUMAN (28-1034): 0: 1198: 57.03		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		665480 EPHA8_HUMAN (60-1036): 0: 1155: 57.78		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		665253 EPHA2_HUMAN (58-1037): 0: 1105: 50.86		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		872537 EPHB4_HUMAN (44-1031): 0: 1056: 47.11		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		600580 EPHA1_HUMAN (47-1028): 0: 995: 41.78		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		171305 EPHB6_HUMAN (43-1023): 0: 944: 38.18		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		1018328 MERTK_HUMAN (295-1003): 1.15e-151: 478: 21.77		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		435654 IGF1R_HUMAN (294-1017): 7.97e-145: 469: 23.00		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		674444 UFO_HUMAN (290-1017): 4.06e-147: 463: 21.89		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		987248 TYRO3_HUMAN (293-975): 8.48e-147: 462: 21.19		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		609305 FGFR3_HUMAN (404-988): 2.12e-147: 461: 21.80		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		972330 TIE2_HUMAN (357-949): 5.11e-141: 453: 26.79		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		442838 HCK_HUMAN (653-933): 1.21e-65: 232: 42.76		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		433785 LYN_HUMAN (659-933): 1.73e-65: 231: 43.68		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		412211 FYN_HUMAN (669-933): 3.12e-64: 229: 44.20		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		411399 INSR_HUMAN (372-515): 2.51e-11: 70.4: 17.09		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00