HitPredict

Interactor 1: AFAD (P55196)
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)
Gene: AFDN

Interactor 2: RIT2 (Q99578)
GTP-binding protein Rit2 (EC 3.6.5.2) (Ras-like protein expressed in neurons) (Ras-like without CAAX protein 2)
Gene: RIT2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	10545207
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DIL~Ras, PDZ~Ras, RA~Ras
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1824 Hs			1 217
+	Hs
		876463 AFAD_HUMAN (1-1824): 0: 1279: 100.00		RIT1_HUMAN (1-217): 2.19e-80: 240: 66.21
+	Hs
		876348 AFAD_HUMAN (1-1824): 0: 1279: 100.00		RAP1A_HUMAN (19-184): 5.08e-53: 170: 47.90
+	Hs
		876344 AFAD_HUMAN (1-1824): 0: 1279: 100.00		RRAS2_HUMAN (17-199): 7.08e-51: 165: 52.43
+	Hs
		156092 AFAD_HUMAN (1-1824): 0: 1279: 100.00		RASM_HUMAN (21-184): 7.76e-48: 157: 52.41
+	Hs
		348594 AFAD_HUMAN (1-1824): 0: 1279: 100.00		RASN_HUMAN (20-183): 1.37e-46: 154: 52.44
+	Hs
		349224 AFAD_HUMAN (1-1824): 0: 1279: 100.00		RASH_HUMAN (20-185): 5e-46: 152: 50.60
+	Hs
		350005 AFAD_HUMAN (1-1824): 0: 1279: 100.00		RASK_HUMAN (20-183): 3.49e-46: 152: 52.44
+	Mm
		140118 AFAD_MOUSE (1-1824): 0: 1234: 92.98		RASM_MOUSE (21-184): 1.5e-47: 157: 52.41
+	Dm
		442960 Q8IPP3_DROME (1-1732): 0: 876: 31.05		RAP1_DROME (19-181): 4.07e-56: 178: 50.31
+	Dm
		442999 Q8IPP3_DROME (1-1732): 0: 876: 31.05		RAS1_DROME (20-203): 2.1e-48: 158: 48.37
+	Dm
		442967 Q95TT5_DROME (1-1642): 0: 835: 32.06		RAP1_DROME (19-181): 4.07e-56: 178: 50.31
+	Dm
		443003 Q95TT5_DROME (1-1642): 0: 835: 32.06		RAS1_DROME (20-203): 2.1e-48: 158: 48.37
+	Hs
		914453 MYO5B_HUMAN (102-939): 4.92e-118: 416: 14.72		RB11A_HUMAN (10-197): 3.52e-77: 232: 25.93
+	Hs
		1079976 MYO5B_HUMAN (102-939): 4.92e-118: 416: 14.72		RB11B_HUMAN (10-193): 2.09e-76: 230: 27.03
+	Hs
		894825 MYO5B_HUMAN (102-939): 4.92e-118: 416: 14.72		RAB8A_HUMAN (13-211): 1.43e-76: 230: 27.94
+	Rn
		914521 MYO5B_RAT (102-939): 4.23e-117: 413: 14.69		RB11A_RAT (10-197): 3.52e-77: 232: 25.93
+	Dm
		442954 Q24279_DROME (639-1315): 3.98e-97: 351: 38.74		RAP1_DROME (19-181): 4.07e-56: 178: 50.31
+	Dm
		442992 Q24279_DROME (639-1315): 3.98e-97: 351: 38.74		RAS1_DROME (20-203): 2.1e-48: 158: 48.37
+	Hs
		914346 KI13A_HUMAN (184-691): 2.35e-70: 264: 13.74		RB11A_HUMAN (10-197): 3.52e-77: 232: 25.93
+	Hs
		349388 RAIN_HUMAN (244-982): 5.22e-96: 336: 16.01		RASH_HUMAN (20-185): 5e-46: 152: 50.60