Interactor 1: AF17 (P55198)
Protein AF-17 (ALL1-fused gene from chromosome 17 protein)
Gene: MLLT6

Interactor 2: DOT1L (Q8TEK3)
Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4)
Gene: DOT1L

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.88 0.60 0.728

The method score is based on:

Property Details
Experiments 26496610, 20203130, 19864429, 28514442, 33961781
Identification Methods affinity chromatography technology, two hybrid, pull down, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 1093
Hs

1 1537
+ Hs
+ Hs
+ Ce

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024