HitPredict - High confidence protein-protein interactions

Interactor 1: NAC3 (P57103)
Sodium/calcium exchanger 3 (Na(+)/Ca(2+)-exchange protein 3) (Solute carrier family 8 member 3)
Gene: SLC8A3

Interactor 2: NAC2 (Q9UPR5)
Sodium/calcium exchanger 2 (Na(+)/Ca(2+)-exchange protein 2) (Solute carrier family 8 member 2)
Gene: SLC8A2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Calx-beta~Calx-beta, Na_Ca_ex~Na_Ca_ex
Common GO terms	GO:0005432 - calcium:sodium antiporter activity GO:0005516 - calmodulin binding GO:0005886 - plasma membrane GO:0007154 - cell communication GO:0006811 - monoatomic ion transport and 22 others more... GO:0006874 - intracellular calcium ion homeostasis GO:0007611 - learning or memory GO:0007612 - learning GO:0007613 - memory GO:0014069 - postsynaptic density GO:0030424 - axon GO:0030425 - dendrite GO:0035725 - sodium ion transmembrane transport GO:0042383 - sarcolemma GO:0043025 - neuronal cell body GO:0043197 - dendritic spine GO:0043204 - perikaryon GO:0043679 - axon terminus GO:0045202 - synapse GO:0046872 - metal ion binding GO:0050808 - synapse organization GO:0060291 - long-term synaptic potentiation GO:0070588 - calcium ion transmembrane transport GO:0098703 - calcium ion import across plasma membrane GO:0098794 - postsynapse GO:0098815 - modulation of excitatory postsynaptic potential GO:1903779 - regulation of cardiac conduction
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1	927
Hs

1	921

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Last updated: 15 Jul 2024