HitPredict

Interactor 1: CD81 (P60033)
CD81 antigen (26 kDa cell surface protein TAPA-1) (Target of the antiproliferative antibody 1) (Tetraspanin-28) (Tspan-28) (CD antigen CD81)
Gene: CD81

Interactor 2: GNAS2 (P63092)
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (Adenylate cyclase-stimulating G alpha protein)
Gene: GNAS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	30024968, 32900848
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 236 Hs			1 394
+	Hs
		887875 CD81_HUMAN (1-236): 6.2e-63: 197: 100.00		GNAS1_HUMAN (11-394): 6.95e-170: 503: 95.05
+	Hs
		391365 CD81_HUMAN (1-236): 6.2e-63: 197: 100.00		GNAI2_HUMAN (1-394): 1.99e-158: 451: 38.83
+	Hs
		887790 CD81_HUMAN (1-236): 6.2e-63: 197: 100.00		GNAI1_HUMAN (1-394): 5.37e-158: 450: 39.09
+	Hs
		444700 CD81_HUMAN (1-236): 6.2e-63: 197: 100.00		GNAI3_HUMAN (1-394): 1.06e-155: 444: 38.58
+	Hs
		837596 CD81_HUMAN (1-236): 6.2e-63: 197: 100.00		GNAQ_HUMAN (11-394): 9.45e-151: 432: 38.02
+	Hs
		670443 CD81_HUMAN (1-236): 6.2e-63: 197: 100.00		GNA11_HUMAN (11-394): 1.04e-146: 421: 38.80
+	Hs
		326032 TSN15_HUMAN (10-230): 9.93e-44: 150: 15.48		GNA11_HUMAN (11-394): 1.04e-146: 421: 38.80