Protein: WDHD1
WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1)

Gene: WDHD1
Organism: Homo sapiens
Interactions: 103
UniProt ID: O75717

Gene Ontology (top 5):
GO:0000278 - mitotic cell cycle
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

291971

NUP50
Nuclear pore complex protein Nup50

4

6

High-throughput

0.694

High

291955

SPI2B
Spindlin-2B

3

1

High-throughput

0.667

High

291896

RFA2
Replication protein A 32 kDa subunit

3

7

Small-scale

0.640

High

291904

RFA1
Replication protein A 70 kDa DNA-binding subunit

3

8

Small-scale

0.640

High

291948

KAT2A
Histone acetyltransferase KAT2A

2

20

Small-scale

0.634

High

291954

CTIP
DNA endonuclease RBBP8

2

1

Small-scale

0.624

High

281155

CDC45
Cell division control protein 45 homolog

1

1

Small-scale

0.618

High

291906

T2EB
Transcription initiation factor IIE subunit beta

2

0

High-throughput

0.602

High

291915

IMA5
Importin subunit alpha-5

2

7

High-throughput

0.601

High

240303

PRKN
E3 ubiquitin-protein ligase parkin

2

17

High-throughput

0.584

High

291910

RFA3
Replication protein A 14 kDa subunit

2

6

High-throughput

0.584

High

291964

CPNE5
Copine-5

2

2

High-throughput

0.574

High

210226

PHF1
PHD finger protein 1

1

6

High-throughput

0.536

High

221904

FOXS1
Forkhead box protein S1

1

10

High-throughput

0.536

High

291889

SLU7
Pre-mRNA-splicing factor SLU7

1

1

High-throughput

0.536

High

291893

S10A6
Protein S100-A6

1

4

High-throughput

0.536

High

291899

RL35A
Large ribosomal subunit protein eL33

1

2

High-throughput

0.536

High

291902

RBTN1
Rhombotin-1

1

3

High-throughput

0.536

High

291917

HSP72
Heat shock-related 70 kDa protein 2

1

12

High-throughput

0.536

High

291922

SSRP1
FACT complex subunit SSRP1

1

20

High-throughput

0.536

High

291924

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

1

High-throughput

0.536

High

291951

EFMT3
EEF1A lysine methyltransferase 3

1

7

High-throughput

0.536

High

291958

TXNIP
Thioredoxin-interacting protein

1

5

High-throughput

0.536

High

291960

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.536

High

291966

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

3

High-throughput

0.536

High

291969

FOXJ2
Forkhead box protein J2

1

11

High-throughput

0.536

High

291945

SMIP5
Sperm-associated microtubule inner protein 5

1

0

High-throughput

0.513

High

291918

SUMO2
Small ubiquitin-related modifier 2

1

5

High-throughput

0.501

High

291890

BAG2
BAG family molecular chaperone regulator 2

1

3

High-throughput

0.489

High

291932

S35G1
Solute carrier family 35 member G1

1

3

High-throughput

0.489

High

291952

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.489

High

291953

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.489

High

291972

AT7L1
Ataxin-7-like protein 1

1

6

High-throughput

0.489

High

291975

CCL26
C-C motif chemokine 26

1

2

High-throughput

0.489

High

128678

MEN1
Menin

1

4

High-throughput

0.479

High

172335

XPO1
Exportin-1

1

20

High-throughput

0.479

High

190766

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

5

High-throughput

0.479

High

256719

H2B1K
Histone H2B type 1-K

1

9

High-throughput

0.479

High

259225

BRD4
Bromodomain-containing protein 4

1

14

High-throughput

0.479

High

291891

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

291894

PARP1
Poly [ADP-ribose] polymerase 1

1

15

High-throughput

0.479

High

291895

TCTP
Translationally-controlled tumor protein

1

1

High-throughput

0.479

High

291897

HSP76
Heat shock 70 kDa protein 6

1

12

High-throughput

0.479

High

291898

CEBPB
CCAAT/enhancer-binding protein beta

1

11

High-throughput

0.479

High

291900

RO52
E3 ubiquitin-protein ligase TRIM21

1

5

High-throughput

0.479

High

291903

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

291905

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

11

High-throughput

0.479

High

291908

MCM7
DNA replication licensing factor MCM7

1

11

Small-scale

0.479

High

291909

CTNB1
Catenin beta-1

1

17

Small-scale

0.479

High

291911

BRCA1
Breast cancer type 1 susceptibility protein

1

15

Small-scale

0.479

High

291912

CDK8
Cyclin-dependent kinase 8

1

9

High-throughput

0.479

High

291913

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2

1

9

Small-scale

0.479

High

291919

H2B1C
Histone H2B type 1-C/E/F/G/I

1

9

High-throughput

0.479

High

291920

ACTC
Actin, alpha cardiac muscle 1

1

6

High-throughput

0.479

High

291923

EP300
Histone acetyltransferase p300

1

8

High-throughput

0.479

High

291925

TIF1B
Transcription intermediary factor 1-beta

1

19

High-throughput

0.479

High

291926

CUL4A
Cullin-4A

1

20

High-throughput

0.479

High

291927

CUL4B
Cullin-4B

1

20

Small-scale

0.479

High

291928

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

10

High-throughput

0.479

High

291929

SUZ12
Polycomb protein SUZ12

1

2

High-throughput

0.479

High

291930

NCOA2
Nuclear receptor coactivator 2

1

9

Small-scale

0.479

High

291931

NCOA1
Nuclear receptor coactivator 1

1

8

Small-scale

0.479

High

291933

H2B2F
Histone H2B type 2-F

1

9

High-throughput

0.479

High

291934

VIR
Protein virilizer homolog

1

4

High-throughput

0.479

High

291935

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

291936

PAXI1
PAX-interacting protein 1

1

13

High-throughput

0.479

High

291937

MOB3C
MOB kinase activator 3C

1

2

High-throughput

0.479

High

291938

H32
Histone H3.2

1

14

Small-scale

0.479

High

291940

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

8

Small-scale

0.479

High

291943

SIR6
NAD-dependent protein deacylase sirtuin-6

1

5

Small-scale

0.479

High

291946

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

291947

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.479

High

291949

RAD50
DNA repair protein RAD50

1

20

Small-scale

0.479

High

291957

TIPIN
TIMELESS-interacting protein

1

1

Small-scale

0.479

High

291959

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

291962

ECT2
Protein ECT2

1

20

High-throughput

0.479

High

291963

CLSPN
Claspin

1

5

Small-scale

0.479

High

291967

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

2

High-throughput

0.479

High

291968

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

2

High-throughput

0.479

High

291970

ZRAN1
Ubiquitin thioesterase ZRANB1

1

13

High-throughput

0.479

High

291973

FZR1
Fizzy-related protein homolog

1

18

High-throughput

0.479

High

261983

NBN
Nibrin

1

0

Small-scale

0.458

High

291950

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

0

High-throughput

0.458

High

291974

TIM
Protein timeless homolog

1

0

Small-scale

0.458

High

129625

CBX4
E3 SUMO-protein ligase CBX4

1

16

High-throughput

0.445

High

291888

VENTX
Homeobox protein VENTX

1

7

High-throughput

0.445

High

291914

IMA1
Importin subunit alpha-1

1

7

High-throughput

0.445

High

291942

DND1
Dead end protein homolog 1

1

6

High-throughput

0.445

High

104967

APRIO
Alternative prion protein

1

5

High-throughput

0.437

High

192409

INSI1
Insulin-induced gene 1 protein

1

3

High-throughput

0.437

High

291892

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.437

High

291907

STIP1
Stress-induced-phosphoprotein 1

1

18

High-throughput

0.437

High

291916

COPB
Coatomer subunit beta

1

7

High-throughput

0.437

High

291939

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

13

High-throughput

0.437

High

291901

KLK2
Kallikrein-2

1

8

High-throughput

0.407

High

291965

CAH10
Carbonic anhydrase-related protein 10

4

0

High-throughput

0.360

High

291956

MGME1
Mitochondrial genome maintenance exonuclease 1

2

0

High-throughput

0.328

High

260711

RAMP1
Receptor activity-modifying protein 1

1

0

High-throughput

0.279

Low

291921

PIGF
GPI ethanolamine phosphate transferase, stabilizing subunit

1

0

High-throughput

0.279

Low

291941

CCD71
Coiled-coil domain-containing protein 71

1

0

High-throughput

0.279

Low

291944

NETO2
Neuropilin and tolloid-like protein 2

1

0

High-throughput

0.279

Low

291961

GREM2
Gremlin-2

1

0

High-throughput

0.279

Low

291976

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025