HitPredict

Interactor 1: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Interactor 2: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 375 Hs			1 776
+	Hs
		1041024 ACTBL_HUMAN (2-375): 0: 735: 91.71		CUL1_HUMAN (1-776): 0: 911: 100.00
+	Hs
		1043394 ACTBL_HUMAN (2-375): 0: 735: 91.71		CUL4B_HUMAN (7-776): 0: 773: 29.90
+	Hs
		932973 ACTS_HUMAN (2-375): 0: 592: 93.58		CUL1_HUMAN (1-776): 0: 911: 100.00
+	Hs
		915376 ACTA_HUMAN (2-375): 0: 591: 94.12		CUL1_HUMAN (1-776): 0: 911: 100.00
+	Hs
		1041722 ACTBL_HUMAN (2-375): 0: 735: 91.71		CUL3_HUMAN (9-776): 0: 748: 30.47
+	Hs
		1041351 ACTBL_HUMAN (2-375): 0: 735: 91.71		CUL2_HUMAN (13-776): 0: 720: 35.98
+	Hs
		891753 ACTB_HUMAN (1-375): 0: 603: 100.00		CUL4B_HUMAN (7-776): 0: 773: 29.90
+	Hs
		915379 ACTA_HUMAN (2-375): 0: 591: 94.12		CUL4B_HUMAN (7-776): 0: 773: 29.90
+	Hs
		1122467 ACTBL_HUMAN (2-375): 0: 735: 91.71		CUL5_HUMAN (2-776): 0: 622: 28.85
+	Hs
		891752 ACTB_HUMAN (1-375): 0: 603: 100.00		CUL3_HUMAN (9-776): 0: 748: 30.47
+	Hs
		915378 ACTA_HUMAN (2-375): 0: 591: 94.12		CUL3_HUMAN (9-776): 0: 748: 30.47
+	Hs
		891751 ACTB_HUMAN (1-375): 0: 603: 100.00		CUL2_HUMAN (13-776): 0: 720: 35.98
+	Hs
		915377 ACTA_HUMAN (2-375): 0: 591: 94.12		CUL2_HUMAN (13-776): 0: 720: 35.98
+	Hs
		891952 ACTB_HUMAN (1-375): 0: 603: 100.00		CUL5_HUMAN (2-776): 0: 622: 28.85