HitPredict

Interactor 1: UBE2K (P61086)
Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)
Gene: UBE2K

Interactor 2: UBA5 (Q9GZZ9)
Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (ThiFP1) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1)
Gene: UBA5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	17825256
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	ThiF~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 200 Hs			1 404
+	Hs
		919856 UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06		UBA5_HUMAN (1-404): 1.8e-151: 436: 100.00
+	Sc
		600929 UBC1_YEAST (6-153): 2.31e-48: 158: 50.34		UBA4_YEAST (9-337): 9.77e-91: 282: 18.13
+	Hs
		919796 UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06		UBA3_HUMAN (6-247): 2.13e-65: 217: 19.77
+	Hs
		1282360 UB2E3_HUMAN (3-153): 8.99e-68: 207: 40.40		SAE2_HUMAN (57-233): 2.97e-53: 189: 26.40
+	Hs
		607041 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Hs
		607026 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Hs
		607190 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Hs
		607050 UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Hs
		607039 UB2D3_HUMAN (4-154): 1.49e-73: 220: 39.74		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Hs
		607136 UB2E2_HUMAN (3-153): 3.57e-68: 208: 40.40		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Hs
		607129 UB2E3_HUMAN (3-153): 8.99e-68: 207: 40.40		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Sp
		293848 UBC4_SCHPO (4-153): 2.34e-73: 219: 42.00		UBA1_SCHPO (35-300): 2e-27: 116: 13.11
+	Sc
		549788 UBC4_YEAST (1-153): 6.39e-73: 218: 41.83		UBA1_YEAST (44-218): 2.65e-27: 116: 19.21
+	Hs
		607023 UBE2A_HUMAN (1-151): 4.98e-67: 203: 30.46		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Hs
		607028 UB2E1_HUMAN (3-153): 1.87e-66: 203: 39.74		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Hs
		607054 UBE2B_HUMAN (1-151): 3.09e-66: 202: 30.46		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Sp
		251976 UBC1_SCHPO (1-157): 5.77e-68: 208: 47.77		UBA1_SCHPO (35-300): 2e-27: 116: 13.11
+	Sc
		600919 UBC1_YEAST (6-153): 2.31e-48: 158: 50.34		UBA1_YEAST (44-218): 2.65e-27: 116: 19.21
+	Hs
		607042 UBE2N_HUMAN (27-153): 1.06e-37: 129: 51.97		UBA1_HUMAN (20-218): 5.28e-32: 130: 13.15
+	Dm
		715098 UBE2N_DROME (43-153): 2.22e-34: 120: 53.15		Q8T0L3_DROME (47-210): 4.46e-18: 88.7: 16.36