HitPredict

Interactor 1: UBE2K (P61086)
Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)
Gene: UBE2K

Interactor 2: RNF41 (Q9H4P4)
E3 ubiquitin-protein ligase NRDP1 (EC 2.3.2.27) (RING finger protein 41) (RING-type E3 ubiquitin transferase NRDP1)
Gene: RNF41

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	19549727, 32814053
Identification Methods	two hybrid, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_2
Common GO terms	GO:0000209 - protein polyubiquitination GO:0004842 - ubiquitin-protein transferase activity GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 200 Hs			1 317
+	Hs
		896370 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRIM5_HUMAN (11-298): 1.5e-56: 192: 19.19
+	Hs
		896348 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRI43_HUMAN (6-294): 6e-55: 186: 14.73
+	Hs
		896381 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRI39_HUMAN (9-271): 2.23e-49: 173: 16.54
+	Hs
		536773 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRI27_HUMAN (3-275): 1.78e-47: 168: 14.75
+	Hs
		135045 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TRI38_HUMAN (3-295): 3.42e-52: 180: 16.56
+	Hs
		896366 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRI34_HUMAN (5-298): 1.44e-43: 157: 17.43
+	Hs
		896394 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRIM1_HUMAN (2-299): 7.77e-40: 150: 16.57
+	Hs
		537142 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TRI27_HUMAN (3-275): 1.78e-47: 168: 14.75
+	Hs
		896369 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRI31_HUMAN (3-275): 1.27e-40: 148: 17.69
+	Hs
		262201 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TRIM3_HUMAN (16-284): 1.77e-39: 149: 14.63
+	Hs
		896330 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRI50_HUMAN (3-208): 1.87e-33: 129: 16.27
+	Hs
		1204911 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TRI50_HUMAN (3-208): 1.87e-33: 129: 16.27
+	Hs
		896320 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		TRAF7_HUMAN (8-137): 1.59e-23: 102: 21.77
+	Hs
		896344 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		RN138_HUMAN (1-108): 1.78e-24: 100: 23.42
+	Hs
		896346 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		RN166_HUMAN (9-118): 8.54e-24: 99.1: 23.42
+	Hs
		1252560 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		LNX1_HUMAN (8-121): 1.33e-26: 111: 27.27
+	Hs
		1163056 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		TRAF7_HUMAN (8-137): 1.59e-23: 102: 21.77
+	Hs
		1261313 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		RN138_HUMAN (1-108): 1.78e-24: 100: 23.42
+	Hs
		1283434 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		RN166_HUMAN (9-118): 8.54e-24: 99.1: 23.42
+	Hs
		896402 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		RN114_HUMAN (16-107): 5.06e-09: 57.8: 31.18