HitPredict

Interactor 1: UBE2K (P61086)
Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)
Gene: UBE2K

Interactor 2: RNF12 (Q9NVW2)
E3 ubiquitin-protein ligase RLIM (EC 2.3.2.27) (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (RING finger protein 12) (RING-type E3 ubiquitin transferase RLIM) (Renal carcinoma antigen NY-REN-43)
Gene: RLIM

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	26592444, 32416094
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 200 Hs			1 624
+	Hs
		1346940 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		RNF12_HUMAN (1-624): 5.62e-119: 368: 100.00
+	Hs
		896337 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		PJA1_HUMAN (79-617): 4.34e-48: 180: 15.56
+	Hs
		896325 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		RN111_HUMAN (73-622): 4.75e-44: 171: 10.53
+	Hs
		196282 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		PJA2_HUMAN (42-617): 1.58e-49: 185: 13.61
+	Hs
		196372 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		PJA2_HUMAN (42-617): 1.58e-49: 185: 13.61
+	Hs
		1169203 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		RN111_HUMAN (73-622): 4.75e-44: 171: 10.53
+	Hs
		849348 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		RN111_HUMAN (73-622): 4.75e-44: 171: 10.53
+	Hs
		1327690 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		RNF38_HUMAN (132-613): 1.34e-43: 165: 14.58
+	Hs
		896377 UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00		RN167_HUMAN (538-614): 1.07e-29: 122: 39.74
+	Hs
		282581 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		RNF8_HUMAN (330-614): 2.23e-34: 138: 11.15
+	Hs
		1313520 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		RN126_HUMAN (364-621): 1.27e-33: 132: 18.08
+	Hs
		1377467 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		RN115_HUMAN (423-621): 3.75e-33: 131: 20.90
+	Hs
		1356934 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		RN150_HUMAN (524-617): 1.55e-31: 129: 31.68
+	Hs
		1204871 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		GOLI_HUMAN (522-617): 2.5e-31: 128: 33.01
+	Hs
		849359 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		GOLI_HUMAN (522-617): 2.5e-31: 128: 33.01
+	Hs
		207545 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		RNF13_HUMAN (550-618): 7.56e-30: 123: 42.86
+	Hs
		207572 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		RNF13_HUMAN (550-618): 7.56e-30: 123: 42.86
+	Hs
		1332598 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		RN167_HUMAN (538-614): 1.07e-29: 122: 39.74
+	Hs
		1262545 UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72		ZNRF4_HUMAN (558-617): 1.08e-10: 66.2: 43.55
+	Hs
		849385 UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74		ZNRF4_HUMAN (558-617): 1.08e-10: 66.2: 43.55