HitPredict

Interactor 1: UBE2N (P61088)
Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubc13) (UbcH13) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N)
Gene: UBE2N

Interactor 2: TIE2 (Q02763)
Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b)
Gene: TEK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology, proximity-dependent biotin identification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:1902533 - positive regulation of intracellular signal transduction
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 152 Hs			1 1124
+	Hs
		674377 UBE2N_HUMAN (1-152): 1.51e-73: 218: 100.00		UFO_HUMAN (330-1106): 3.07e-162: 505: 23.47
+	Hs
		609235 UBE2N_HUMAN (1-152): 1.51e-73: 218: 100.00		FGFR3_HUMAN (350-1118): 1.89e-157: 490: 24.44
+	Hs
		896558 UBE2N_HUMAN (1-152): 1.51e-73: 218: 100.00		EPHA6_HUMAN (518-1122): 5.91e-155: 490: 22.07
+	Hs
		609211 UBE2A_HUMAN (1-146): 5.35e-70: 209: 39.46		FGFR3_HUMAN (350-1118): 1.89e-157: 490: 24.44
+	Hs
		445838 UBE2N_HUMAN (1-152): 1.51e-73: 218: 100.00		ROS1_HUMAN (448-1123): 1.09e-128: 437: 24.41
+	Hs
		896423 UBE2N_HUMAN (1-152): 1.51e-73: 218: 100.00		MERTK_HUMAN (350-632): 2.4e-17: 89.7: 16.89