HitPredict

Interactor 1: NCK2 (O55033)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: DYN1 (P39053)
Dynamin-1 (EC 3.6.5.5) (Dynamin) (Dynamin I)
Gene: Dnm1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.555

Property	Details
Experiments	11557983
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Mm			1 867
+	Hs
		222060 NCK2_HUMAN (1-380): 6.22e-94: 287: 96.05		DYN1_HUMAN (1-845): 0: 1050: 99.65
+	Hs
		593970 NCK1_HUMAN (1-379): 1.44e-89: 276: 66.40		DYN1_HUMAN (1-845): 0: 1050: 99.65
+	Mm
		810542 ITSN1_MOUSE (5-306): 2.47e-27: 116: 15.26		DYN1_MOUSE (1-867): 0: 1086: 100.00
+	Rn
		638959 P85A_RAT (26-379): 3.94e-27: 115: 12.33		DYN1_RAT (1-845): 0: 1042: 98.34
+	Rn
		638964 ITSN1_RAT (5-306): 1.04e-26: 114: 15.80		DYN1_RAT (1-845): 0: 1042: 98.34
+	Hs
		1050684 ITSN1_HUMAN (4-305): 8.39e-23: 102: 15.78		DYN1_HUMAN (1-845): 0: 1050: 99.65
+	Ce
		810580 Q95PW9_CAEEL (1-379): 1.16e-73: 236: 38.38		DYN1_CAEEL (3-799): 0: 897: 64.25
+	Hs
		896907 ITSN2_HUMAN (5-306): 2.8e-33: 133: 18.51		DYN2_HUMAN (1-845): 0: 983: 77.93
+	Mm
		810562 ITSN1_MOUSE (5-306): 2.47e-27: 116: 15.26		DYN2_MOUSE (1-845): 0: 985: 78.28
+	Hs
		699652 P85A_HUMAN (26-379): 1.65e-27: 116: 12.33		DYN2_HUMAN (1-845): 0: 983: 77.93
+	Hs
		896763 ITSN1_HUMAN (4-305): 8.39e-23: 102: 15.78		DYN2_HUMAN (1-845): 0: 983: 77.93
+	Hs
		896746 GRAP_HUMAN (5-169): 1.63e-24: 101: 15.74		DYN2_HUMAN (1-845): 0: 983: 77.93
+	Hs
		473383 HCK_HUMAN (2-205): 2.38e-21: 97.6: 18.93		DYN2_HUMAN (1-845): 0: 983: 77.93
+	Hs
		440447 FYN_HUMAN (7-205): 9.84e-21: 95.6: 12.68		DYN2_HUMAN (1-845): 0: 983: 77.93
+	Hs
		440790 FYN_HUMAN (7-205): 9.84e-21: 95.6: 12.68		DYN3_HUMAN (1-839): 0: 978: 78.64
+	Dm
		693526 GRAP_DROME (204-368): 5.68e-18: 83.6: 32.53		DYN_DROME (6-845): 0: 921: 65.93
+	Dm
		118279 M9ND00_DROME (1-75): 1.78e-16: 83.2: 27.27		DYN_DROME (6-845): 0: 921: 65.93
+	Dm
		263714 O61618_DROME (1-65): 2.41e-16: 82.8: 32.84		DYN_DROME (6-845): 0: 921: 65.93
+	Ce
		234032 SRC2_CAEEL (1-205): 1.24e-19: 92.2: 15.57		DYN1_CAEEL (3-799): 0: 897: 64.25
+	Ce
		711448 SEM5_CAEEL (204-364): 1.27e-16: 80.1: 31.29		DYN1_CAEEL (3-799): 0: 897: 64.25