HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: RHG26 (Q9UNA1)
Rho GTPase-activating protein 26 (GTPase regulator associated with focal adhesion kinase) (GRAF1) (Oligophrenin-1-like protein) (Rho-type GTPase-activating protein 26)
Gene: ARHGAP26

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	11432776, 32203420
Identification Methods	enzymatic study, fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGAP
Common GO terms	GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0005925 - focal adhesion GO:0030036 - actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 814
+	Hs
		49631 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG10_HUMAN (1-814): 1.38e-178: 534: 53.65
+	Hs
		63073 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		RHG42_HUMAN (1-814): 1.3e-177: 535: 48.91
+	Hs
		245183 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		OPHN1_HUMAN (1-790): 1.86e-159: 485: 42.79
+	Hs
		900637 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		SRGP1_HUMAN (24-773): 4.65e-86: 297: 14.63
+	Hs
		900997 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		GMIP_HUMAN (1-767): 4.39e-83: 287: 14.63
+	Mm
		1265268 RHOA_MOUSE (1-193): 4.1e-81: 240: 99.48		SRGP1_MOUSE (24-751): 4.62e-81: 283: 14.84
+	Hs
		900564 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG21_HUMAN (325-784): 5.63e-75: 269: 18.24
+	Hs
		64681 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG32_HUMAN (338-740): 1.15e-71: 259: 21.41
+	Hs
		900540 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG29_HUMAN (11-737): 4.71e-72: 259: 14.27
+	Hs
		64688 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		RHG32_HUMAN (338-740): 1.15e-71: 259: 21.41
+	Hs
		147862 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		RHG33_HUMAN (351-738): 1.31e-71: 258: 22.50
+	Mm
		925803 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		RHG32_MOUSE (338-740): 6.36e-71: 257: 21.48
+	Mm
		925805 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		RHG22_MOUSE (237-746): 9.4e-74: 256: 16.07
+	Mm
		925802 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		CHIO_MOUSE (389-568): 1.2e-73: 245: 35.91
+	Hs
		70663 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		MYO9A_HUMAN (125-780): 4.7e-63: 233: 12.59
+	Hs
		900634 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG22_HUMAN (236-778): 2.8e-65: 233: 14.97
+	Hs
		900954 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG35_HUMAN (393-572): 4.62e-21: 101: 28.33
+	Hs
		506561 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		BCR_HUMAN (392-542): 1.09e-18: 93.6: 34.44
+	Mm
		925798 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		BCR_MOUSE (392-542): 1.2e-18: 93.6: 34.44
+	Mm
		925793 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		ABR_MOUSE (392-541): 1.22e-18: 93.2: 36.00