HitPredict

Interactor 1: SUMO2 (P61956)
Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B)
Gene: SUMO2

Interactor 2: UBP25 (Q9UHP3)
Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (USP on chromosome 21) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25)
Gene: USP25

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.721

Property	Details
Experiments	25416956, 28538147, 32296183, 18538659, unassigned1304
Identification Methods	two hybrid, pull down, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 95 Hs			1 1055
+	Hs
		879163 SUMO3_HUMAN (1-94): 3.76e-41: 132: 96.81		UBP25_HUMAN (1-1055): 0: 1021: 100.00
+	Hs
		928224 SUMO1_HUMAN (1-93): 7.76e-35: 116: 45.36		UBP25_HUMAN (1-1055): 0: 1021: 100.00
+	Hs
		902725 SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00		UBP28_HUMAN (1-1047): 0: 894: 48.57
+	Hs
		800569 SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00		UBP5_HUMAN (148-656): 1.28e-85: 297: 15.09
+	Hs
		902707 SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00		USP9X_HUMAN (142-459): 2.23e-67: 250: 20.22
+	Hs
		902655 SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00		UBP48_HUMAN (157-406): 1.37e-66: 245: 25.86
+	Hs
		902708 SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00		UBP7_HUMAN (547-758): 1.65e-17: 90.2: 21.78
+	Hs
		902780 SUMO2_HUMAN (1-95): 3.56e-44: 139: 100.00		UBP36_HUMAN (560-684): 1.95e-11: 70.7: 22.84