HitPredict

Interactor 1: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Interactor 2: TSC1 (Q92574)
Hamartin (Tuberous sclerosis 1 protein)
Gene: TSC1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.714

Property	Details
Experiments	33961781, 35271311, 15324660, 17353931, 28514442
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:1904262 - negative regulation of TORC1 signaling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 247 Hs			1 1164
+	Hs
		909871 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		TSC1_HUMAN (1-1164): 0: 725: 100.00
+	Mm
		910338 1433E_MOUSE (1-244): 2.02e-141: 398: 63.53		TSC1_MOUSE (1-1164): 0: 695: 86.98
+	Hs
		909555 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		DCTN1_HUMAN (540-1022): 9.26e-59: 223: 16.33
+	Hs
		909488 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		CGNL1_HUMAN (280-1054): 5.93e-34: 144: 11.22
+	Hs
		904495 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		CGNL1_HUMAN (280-1054): 5.93e-34: 144: 11.22
+	Hs
		728460 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		MYH11_HUMAN (392-1122): 2.73e-28: 126: 8.64
+	Hs
		728471 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		MYH11_HUMAN (392-1122): 2.73e-28: 126: 8.64
+	Hs
		551656 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		DESP_HUMAN (570-1151): 1.05e-21: 104: 11.54
+	Hs
		909658 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		MRCKA_HUMAN (278-842): 4.78e-17: 89.1: 8.78
+	Hs
		551677 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		DESP_HUMAN (570-1151): 1.05e-21: 104: 11.54
+	Hs
		904690 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		MRCKA_HUMAN (278-842): 4.78e-17: 89.1: 8.78
+	Hs
		909524 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		ROCK1_HUMAN (433-926): 6.18e-15: 82.2: 12.00
+	Hs
		909755 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		PHLB1_HUMAN (280-850): 6.61e-14: 79.1: 11.33
+	Mm
		93548 1433E_MOUSE (1-244): 2.02e-141: 398: 63.53		DESP_MOUSE (718-1164): 2.9e-13: 77.2: 10.89
+	Hs
		909641 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		CYTSB_HUMAN (740-1117): 1.86e-12: 74.1: 12.41
+	Hs
		904795 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		PHLB1_HUMAN (280-850): 6.61e-14: 79.1: 11.33
+	Hs
		904665 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		CYTSB_HUMAN (740-1117): 1.86e-12: 74.1: 12.41
+	Hs
		725130 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		MYH10_HUMAN (687-992): 3.26e-09: 63.6: 20.43
+	Dm
		955019 1433E_DROME (1-243): 1.58e-140: 396: 63.37		Q9VCC9_DROME (835-1160): 2.53e-09: 63.7: 9.76
+	Hs
		725128 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		MYH10_HUMAN (687-992): 3.26e-09: 63.6: 20.43