HitPredict

Interactor 1: 1433E (P62259)
14-3-3 protein epsilon (14-3-3E)
Gene: Ywhae

Interactor 2: KSR1 (Q61097)
Kinase suppressor of Ras 1 (mKSR1) (EC 2.7.11.1) (Protein Hb)
Gene: KSR1

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	16944949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0005783 - endoplasmic reticulum GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 255 Mm			1 873
+	Hs
		909779 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		KSR1_HUMAN (1-873): 0: 695: 85.17
+	Hs
		909702 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		KSR2_HUMAN (31-848): 3.41e-177: 538: 42.37
+	Gg
		982842 1433E_CHICK (1-255): 4.87e-154: 430: 100.00		BRAF_CHICK (98-854): 1.25e-151: 466: 22.49
+	Hs
		110869 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		H7C560_HUMAN (123-854): 7.65e-151: 464: 22.84
+	Hs
		542849 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		BRAF_HUMAN (123-854): 1.9e-150: 463: 22.84
+	Mm
		655938 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		BRAF_MOUSE (123-854): 3.96e-146: 451: 22.46
+	Hs
		373995 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		RAF1_HUMAN (240-858): 1.26e-144: 444: 24.45
+	Hs
		488645 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		ARAF_HUMAN (234-849): 1.06e-137: 424: 24.88
+	Dm
		507708 1433E_DROME (1-254): 2.95e-146: 411: 82.69		KRAF1_DROME (230-858): 1.82e-121: 386: 22.85
+	Hs
		411661 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		LCK_HUMAN (541-840): 8.67e-98: 317: 23.93