HitPredict

Interactor 1: IMA5 (P52294)
Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed]
Gene: KPNA1

Interactor 2: EPAS1 (Q99814)
Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2)
Gene: EPAS1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	18187047
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 538 Hs			1 870
+	Hs
		253683 IMA7_HUMAN (1-538): 1.96e-160: 469: 80.48		EPAS1_HUMAN (1-870): 0: 868: 100.00
+	Hs
		179075 IMA6_HUMAN (1-538): 3.86e-153: 450: 79.59		EPAS1_HUMAN (1-870): 0: 868: 100.00
+	Hs
		138757 IMA4_HUMAN (3-538): 5.05e-151: 444: 45.91		EPAS1_HUMAN (1-870): 0: 868: 100.00
+	Hs
		253640 IMA7_HUMAN (1-538): 1.96e-160: 469: 80.48		HIF1A_HUMAN (3-787): 0: 559: 43.91
+	Hs
		142562 IMA3_HUMAN (1-538): 2.06e-156: 458: 45.84		HIF1A_HUMAN (3-787): 0: 559: 43.91
+	Hs
		911257 IMA5_HUMAN (1-538): 2.92e-156: 458: 100.00		HIF1A_HUMAN (3-787): 0: 559: 43.91
+	Hs
		179052 IMA6_HUMAN (1-538): 3.86e-153: 450: 79.59		HIF1A_HUMAN (3-787): 0: 559: 43.91
+	Hs
		138699 IMA4_HUMAN (3-538): 5.05e-151: 444: 45.91		HIF1A_HUMAN (3-787): 0: 559: 43.91
+	Hs
		253585 IMA7_HUMAN (1-538): 1.96e-160: 469: 80.48		ARNT_HUMAN (2-644): 6.75e-131: 412: 19.24
+	Hs
		693275 IMA5_HUMAN (1-538): 2.92e-156: 458: 100.00		ARNT_HUMAN (2-644): 6.75e-131: 412: 19.24
+	Hs
		179027 IMA6_HUMAN (1-538): 3.86e-153: 450: 79.59		ARNT_HUMAN (2-644): 6.75e-131: 412: 19.24
+	Hs
		138630 IMA4_HUMAN (3-538): 5.05e-151: 444: 45.91		ARNT_HUMAN (2-644): 6.75e-131: 412: 19.24
+	Dm
		1172642 Q9V455_DROME (4-538): 3e-147: 434: 44.49		SIMA_DROME (2-492): 2.36e-95: 330: 31.18