HitPredict

Interactor 1: EFNA5 (P52803)
Ephrin-A5 (AL-1) (EPH-related receptor tyrosine kinase ligand 7) (LERK-7)
Gene: EFNA5

Interactor 2: EPHB1 (P54762)
Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (EPH tyrosine kinase 2) (EPH-like kinase 6) (EK6) (hEK6) (Neuronally-expressed EPH-related tyrosine kinase) (NET) (Tyrosine-protein kinase receptor EPH-2)
Gene: EPHB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9245480
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ephrin~Ephrin_lbd
Common GO terms	GO:0005886 - plasma membrane GO:0007411 - axon guidance GO:0031290 - retinal ganglion cell axon guidance GO:0048013 - ephrin receptor signaling pathway GO:0051965 - positive regulation of synapse assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 228 Hs			1 984
+	Mm
		147436 EFNA5_MOUSE (1-213): 5.95e-110: 316: 99.06		EPHB2_MOUSE (19-981): 0: 1174: 73.86
+	Hs
		914525 EFNA5_HUMAN (1-213): 2.86e-110: 317: 100.00		EPHA5_HUMAN (1-983): 0: 1133: 55.67
+	Mm
		147437 EFNA5_MOUSE (1-213): 5.95e-110: 316: 99.06		EPHA7_MOUSE (1-981): 0: 1130: 57.36
+	Hs
		914536 EFNA5_HUMAN (1-213): 2.86e-110: 317: 100.00		EPHA7_HUMAN (1-981): 0: 1128: 56.96
+	Hs
		914527 EFNA5_HUMAN (1-213): 2.86e-110: 317: 100.00		EPHA4_HUMAN (13-983): 0: 1127: 59.10
+	Dr
		1009395 EFNA5_DANRE (1-215): 2.66e-98: 287: 76.74		Q5ZEW1_DANRE (8-983): 0: 1156: 58.69
+	Hs
		710611 EFNA5_HUMAN (1-213): 2.86e-110: 317: 100.00		EPHA3_HUMAN (14-983): 0: 1117: 55.56
+	Mm
		147438 EFNA5_MOUSE (1-213): 5.95e-110: 316: 99.06		Q8BRB1_MOUSE (4-983): 0: 1108: 55.00
+	Hs
		710810 EFNB1_HUMAN (9-207): 1.81e-73: 228: 25.74		EPHB2_HUMAN (19-981): 0: 1173: 73.76
+	Dr
		47666 EFNA5_DANRE (1-215): 2.66e-98: 287: 76.74		A0A8M9PHF0_DANRE (1-981): 0: 1112: 55.58
+	Hs
		914560 EFNA5_HUMAN (1-213): 2.86e-110: 317: 100.00		EPHA6_HUMAN (1-982): 0: 1076: 51.65
+	Dr
		148813 EFNA5_DANRE (1-215): 2.66e-98: 287: 76.74		EPHA3_DANRE (3-976): 0: 1090: 54.14
+	Hs
		710690 EFNA5_HUMAN (1-213): 2.86e-110: 317: 100.00		EPHA8_HUMAN (19-982): 0: 1051: 51.73
+	Hs
		914198 EFNA3_HUMAN (25-225): 8.63e-75: 228: 38.79		EPHA7_HUMAN (1-981): 0: 1128: 56.96
+	Hs
		710608 EFNA3_HUMAN (25-225): 8.63e-75: 228: 38.79		EPHA3_HUMAN (14-983): 0: 1117: 55.56
+	Hs
		710619 EFNB1_HUMAN (9-207): 1.81e-73: 228: 25.74		EPHA3_HUMAN (14-983): 0: 1117: 55.56
+	Hs
		931807 EFNB1_HUMAN (9-207): 1.81e-73: 228: 25.74		EPHB3_HUMAN (16-979): 0: 1111: 70.56
+	Hs
		710136 EFNA5_HUMAN (1-213): 2.86e-110: 317: 100.00		EPHA2_HUMAN (17-977): 0: 1008: 46.74
+	Hs
		710133 EFNA3_HUMAN (25-225): 8.63e-75: 228: 38.79		EPHA2_HUMAN (17-977): 0: 1008: 46.74
+	Hs
		720192 EFNB1_HUMAN (9-207): 1.81e-73: 228: 25.74		UFO_HUMAN (131-963): 1.57e-168: 517: 23.10