HitPredict

Interactor 1: KBTBD (C9JR72)
Kelch repeat and BTB domain-containing protein 13
Gene: KBTBD13

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	22542517, 30190310
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, cosedimentation in solution, molecular sieving, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	BTB~Cullin
Common GO terms	GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 458 Hs			1 768
+	Hs
		1114569 KLHL3_HUMAN (2-442): 1.27e-95: 301: 13.84		CUL3_HUMAN (1-768): 0: 943: 100.00
+	Hs
		317761 KBTBB_HUMAN (6-448): 4.82e-87: 280: 21.95		CUL3_HUMAN (1-768): 0: 943: 100.00
+	Hs
		1113271 KLH22_HUMAN (58-444): 4.05e-86: 278: 21.04		CUL3_HUMAN (1-768): 0: 943: 100.00
+	Hs
		1114520 KLHL9_HUMAN (3-458): 7.56e-85: 274: 16.46		CUL3_HUMAN (1-768): 0: 943: 100.00
+	Hs
		1114525 KLH13_HUMAN (3-458): 1.22e-84: 274: 15.94		CUL3_HUMAN (1-768): 0: 943: 100.00
+	Hs
		1114523 KLH42_HUMAN (6-430): 1.96e-85: 272: 24.59		CUL3_HUMAN (1-768): 0: 943: 100.00
+	Hs
		1114239 KLHL4_HUMAN (40-444): 2.19e-77: 257: 18.29		CUL3_HUMAN (1-768): 0: 943: 100.00
+	Hs
		1114702 KLH20_HUMAN (40-442): 6.28e-72: 240: 16.99		CUL3_HUMAN (1-768): 0: 943: 100.00
+	Hs
		1113453 KLH17_HUMAN (20-456): 6.89e-70: 235: 18.99		CUL3_HUMAN (1-768): 0: 943: 100.00
+	Rn
		81587 KLH17_RAT (20-456): 2.19e-70: 236: 18.54		CUL3_RAT (1-768): 0: 942: 99.61
+	Hs
		320822 KLH18_HUMAN (33-439): 5.17e-70: 234: 15.35		CUL3_HUMAN (1-768): 0: 943: 100.00
+	Dm
		1047180 KELC_DROME (45-443): 2.69e-77: 264: 18.25		Q8IP45_DROME (17-768): 0: 857: 69.08
+	Hs
		1115120 KLHL3_HUMAN (2-442): 1.27e-95: 301: 13.84		CUL4A_HUMAN (10-768): 0: 801: 38.32
+	Hs
		1115110 KLHL9_HUMAN (3-458): 7.56e-85: 274: 16.46		CUL4A_HUMAN (10-768): 0: 801: 38.32
+	Hs
		1112752 KLH13_HUMAN (3-458): 1.22e-84: 274: 15.94		CUL1_HUMAN (18-768): 0: 709: 30.57
+	Hs
		1112703 KLHL4_HUMAN (40-444): 2.19e-77: 257: 18.29		CUL1_HUMAN (18-768): 0: 709: 30.57
+	Rn
		73324 KLH17_RAT (20-456): 2.19e-70: 236: 18.54		B1WBY1_RAT (17-768): 0: 710: 30.53
+	Hs
		1112478 KEAP1_HUMAN (60-441): 1.51e-69: 234: 16.29		CUL1_HUMAN (18-768): 0: 709: 30.57
+	Hs
		1371887 KLH42_HUMAN (6-430): 1.96e-85: 272: 24.59		CUL5_HUMAN (25-768): 0: 597: 23.77
+	Hs
		320836 KLH18_HUMAN (33-439): 5.17e-70: 234: 15.35		CUL5_HUMAN (25-768): 0: 597: 23.77