Protein: KLH42
Kelch-like protein 42 (Cullin-3-binding protein 9) (Ctb9) (Kelch domain-containing protein 5)

Gene: KLH42, KLHL42
Organism: Homo sapiens
Interactions: 93
UniProt ID: Q9P2K6

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0005819 - spindle
GO:0005829 - cytosol
GO:0031463 - Cul3-RING ubiquitin ligase complex
GO:0032886 - regulation of microtubule-based process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1114523

CUL3
Cullin-3

14

20

Small-scale

0.981

High

1454690

UBQL1
Ubiquilin-1

4

8

High-throughput

0.705

High

1371887

CUL5
Cullin-5

1

20

High-throughput

0.691

High

296585

STAM2
Signal transducing adapter molecule 2

3

2

High-throughput

0.675

High

643575

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

3

4

High-throughput

0.667

High

957535

UBC12
NEDD8-conjugating enzyme Ubc12

3

18

High-throughput

0.667

High

1414940

RN126
E3 ubiquitin-protein ligase RNF126

3

1

High-throughput

0.667

High

1272582

CSN6
COP9 signalosome complex subunit 6

3

13

High-throughput

0.662

High

1370427

CSN5
COP9 signalosome complex subunit 5

3

14

Small-scale

0.650

High

1369909

OSTF1
Osteoclast-stimulating factor 1

4

12

High-throughput

0.632

High

885911

KC1E
Casein kinase I isoform epsilon

2

7

High-throughput

0.628

High

1454693

KLDC2
Kelch domain-containing protein 2

2

18

High-throughput

0.628

High

783439

TRI23
E3 ubiquitin-protein ligase TRIM23

3

1

High-throughput

0.616

High

1356076

DDI1
Protein DDI1 homolog 1

3

8

High-throughput

0.616

High

354793

PAK4
Serine/threonine-protein kinase PAK 4

2

8

High-throughput

0.611

High

984001

RBX1
E3 ubiquitin-protein ligase RBX1

2

9

Small-scale

0.611

High

1404991

GA2L1
GAS2-like protein 1

3

5

High-throughput

0.609

High

452419

PDIA1
Protein disulfide-isomerase

2

2

High-throughput

0.606

High

1049037

REL
Proto-oncogene c-Rel

2

3

High-throughput

0.606

High

1277097

PANKY
Photoreceptor ankyrin repeat protein

2

5

High-throughput

0.606

High

1417031

CDCA4
Cell division cycle-associated protein 4

2

1

High-throughput

0.606

High

1454684

UBQL2
Ubiquilin-2

2

8

High-throughput

0.606

High

577392

OXDA
D-amino-acid oxidase

2

0

High-throughput

0.602

High

1371209

GLMN
Glomulin

2

0

High-throughput

0.602

High

1094433

CSN1
COP9 signalosome complex subunit 1

2

18

High-throughput

0.601

High

217218

MS18B
Protein Mis18-beta

2

0

High-throughput

0.580

High

1186935

KR194
Keratin-associated protein 19-4

2

0

High-throughput

0.580

High

1323366

VPS52
Vacuolar protein sorting-associated protein 52 homolog

2

0

High-throughput

0.580

High

1404685

PFD5
Prefoldin subunit 5

2

0

High-throughput

0.580

High

1219154

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

2

1

High-throughput

0.574

High

1095830

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

9

High-throughput

0.573

High

1454691

CSN3
COP9 signalosome complex subunit 3

2

20

High-throughput

0.571

High

581797

MYOG
Myogenin

2

1

High-throughput

0.553

High

605157

KCRS
Creatine kinase S-type, mitochondrial

2

1

High-throughput

0.553

High

1081506

INCA1
Protein INCA1

2

1

High-throughput

0.553

High

1220056

TTC23
Tetratricopeptide repeat protein 23

2

1

High-throughput

0.553

High

1419246

TRI54
Tripartite motif-containing protein 54

2

11

High-throughput

0.553

High

1448800

UBQL4
Ubiquilin-4

1

9

High-throughput

0.541

High

456875

ANXA2
Annexin A2

1

2

High-throughput

0.536

High

940469

TCL1A
T-cell leukemia/lymphoma protein 1A

1

1

High-throughput

0.536

High

946468

MTPN
Myotrophin

1

7

High-throughput

0.536

High

1193137

PKHN1
Pleckstrin homology domain-containing family N member 1

1

4

High-throughput

0.536

High

1307226

RN135
E3 ubiquitin-protein ligase RNF135

1

5

High-throughput

0.536

High

1391967

DCNL1
DCN1-like protein 1

1

12

High-throughput

0.536

High

1430015

ARL6
ADP-ribosylation factor-like protein 6

1

1

High-throughput

0.536

High

1435638

SYNCI
Syncoilin

1

5

High-throughput

0.536

High

1257306

STXB4
Syntaxin-binding protein 4

2

5

High-throughput

0.526

High

1332121

EIF1A
Probable RNA-binding protein EIF1AD

1

0

High-throughput

0.513

High

1352586

AF1L1
Actin filament-associated protein 1-like 1

1

0

High-throughput

0.513

High

1381213

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

6

Small-scale

0.501

High

800142

COIL
Coilin

1

1

High-throughput

0.494

High

1330107

USBP1
Harmonin-binding protein USHBP1

1

5

High-throughput

0.494

High

1386988

RCN3
Reticulocalbin-3

1

1

High-throughput

0.494

High

164779

GDF8
Growth/differentiation factor 8

1

1

High-throughput

0.489

High

939911

DLX6
Homeobox protein DLX-6

1

1

High-throughput

0.489

High

1200340

ANR39
Ankyrin repeat domain-containing protein 39

1

5

High-throughput

0.489

High

1202608

TNI3K
Serine/threonine-protein kinase TNNI3K

1

2

High-throughput

0.489

High

1244463

DCNL2
DCN1-like protein 2

1

12

High-throughput

0.489

High

1254166

SHSA6
Protein shisa-6

1

1

High-throughput

0.489

High

1322366

ZN444
Zinc finger protein 444

1

6

High-throughput

0.489

High

1360020

IL1FA
Interleukin-1 family member 10

1

1

High-throughput

0.489

High

1414167

ISCA1
Iron-sulfur cluster assembly 1 homolog, mitochondrial

1

1

High-throughput

0.489

High

774122

ADDA
Alpha-adducin

1

3

High-throughput

0.481

High

282496

KTNA1
Katanin p60 ATPase-containing subunit A1

1

2

Small-scale

0.479

High

1340826

COP1
E3 ubiquitin-protein ligase COP1

1

3

High-throughput

0.479

High

1413210

CSN4
COP9 signalosome complex subunit 4

1

4

High-throughput

0.479

High

1065900

Q08AL9
Syntaxin-binding protein 4

1

5

High-throughput

0.470

High

1386998

Q96D30
Alpha-adducin

1

2

High-throughput

0.470

High

636899

GSTM3
Glutathione S-transferase Mu 3

1

0

High-throughput

0.458

High

958727

CSN2
COP9 signalosome complex subunit 2

1

20

High-throughput

0.445

High

1454683

RBX2
RING-box protein 2

1

12

High-throughput

0.445

High

589919

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

1206690

LRC73
Leucine-rich repeat-containing protein 73

1

2

High-throughput

0.407

High

1454686

SRTD1
SERTA domain-containing protein 1

3

0

High-throughput

0.348

High

1454687

TEKT2
Tektin-2

3

0

High-throughput

0.347

High

279527

TULP3
Tubby-related protein 3

2

0

High-throughput

0.328

High

1356812

NEUFC
Neuferricin

2

0

High-throughput

0.328

High

1438599

MRM3
rRNA methyltransferase 3, mitochondrial

2

0

High-throughput

0.328

High

377073

COLI
Pro-opiomelanocortin

2

0

High-throughput

0.316

High

1139155

DAZP2
DAZ-associated protein 2

2

0

High-throughput

0.316

High

1356629

CT55
Cancer/testis antigen 55

2

0

High-throughput

0.316

High

1454688

SRTD3
SERTA domain-containing protein 3

2

0

High-throughput

0.316

High

1454685

TCAL9
Transcription elongation factor A protein-like 9

2

0

High-throughput

0.313

High

1364837

F168A
Protein FAM168A

1

0

High-throughput

0.299

High

1454692

ADIP
Afadin- and alpha-actinin-binding protein

1

0

High-throughput

0.299

High

270693

ATP9A
Probable phospholipid-transporting ATPase IIA

1

0

High-throughput

0.279

Low

415132

MT1F
Metallothionein-1F

1

0

High-throughput

0.279

Low

1213726

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

0

High-throughput

0.279

Low

1295423

RAB43
Ras-related protein Rab-43

1

0

High-throughput

0.279

Low

1420855

SEM4C
Semaphorin-4C

1

0

High-throughput

0.279

Low

1450676

EVA1B
Protein eva-1 homolog B

1

0

High-throughput

0.279

Low

1454689

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.279

Low

696739

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025