HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: KLHL3 (Q9UH77)
Kelch-like protein 3
Gene: KLHL3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.987

The method score is based on:

Property Details
Experiments 26286618, 33961781, 34878901, 35563538, 23387299, 23573258, 23576762, 25250572, 25416956, 26100637, 23665031, 30819806, 32296183, 23453970, 23838290, 31515488, 25502805, unassigned1304
Identification Methods pull down, affinity chromatography technology, enzymatic study, x-ray crystallography, two hybrid, fluorescent resonance energy transfer, two hybrid array, anti tag coimmunoprecipitation, two hybrid prey pooling approach, validated two hybrid
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains BACK~Cullin, BTB~Cullin
Common GO terms GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0010467 - gene expression
GO:0016567 - protein ubiquitination
and 3 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Service provided by Combinatics, Japan

Last updated: 11Aug2025