HitPredict

Interactor 1: RAN (P62826)
GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
Gene: RAN

Interactor 2: NUP50 (Q9UKX7)
Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50)
Gene: NUP50

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ran_BP1~Ras
Common GO terms	GO:0005635 - nuclear envelope GO:0005643 - nuclear pore GO:0005654 - nucleoplasm GO:0006606 - protein import into nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 216 Hs			1 468
+	At
		784991 RAN1_ARATH (1-216): 1.39e-95: 279: 73.52		NU50A_ARATH (3-468): 5.16e-44: 161: 17.60
+	At
		784994 RAN1_ARATH (1-216): 1.39e-95: 279: 73.52		RBP1A_ARATH (314-464): 8.17e-40: 144: 21.02
+	At
		784989 RAN1_ARATH (1-216): 1.39e-95: 279: 73.52		RBP1B_ARATH (315-464): 7.09e-34: 128: 21.15
+	At
		785000 RAN2_ARATH (1-215): 1.36e-88: 261: 74.77		RBP1A_ARATH (314-464): 8.17e-40: 144: 21.02
+	Sc
		691616 GSP1_YEAST (1-214): 5.23e-83: 247: 80.56		NUP2_YEAST (46-466): 3.73e-38: 149: 15.51
+	Hs
		483392 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		RGPD1_HUMAN (212-468): 1.43e-40: 157: 17.23
+	At
		1210455 RAN3_ARATH (1-215): 9.1e-84: 249: 74.31		RBP1A_ARATH (314-464): 8.17e-40: 144: 21.02
+	Hs
		152774 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		RGPD8_HUMAN (196-468): 2.51e-39: 154: 14.34
+	Hs
		483422 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		RGPD2_HUMAN (212-468): 2.93e-39: 153: 17.23
+	Hs
		63882 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		RGPD3_HUMAN (196-468): 4.76e-39: 153: 14.69
+	At
		784998 RAN2_ARATH (1-215): 1.36e-88: 261: 74.77		RBP1B_ARATH (315-464): 7.09e-34: 128: 21.15
+	Hs
		796725 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		RANG_HUMAN (316-466): 8.74e-42: 149: 19.38
+	Hs
		834710 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		RBP2_HUMAN (212-468): 1.6e-36: 146: 17.60
+	Ce
		184992 RAN_CAEEL (3-205): 3.44e-97: 283: 88.18		Q21021_CAEEL (257-465): 1.12e-19: 94.4: 15.74
+	At
		1210453 RAN3_ARATH (1-215): 9.1e-84: 249: 74.31		RBP1B_ARATH (315-464): 7.09e-34: 128: 21.15
+	Xl
		193796 RAN_XENLA (1-216): 7.81e-80: 239: 98.15		O42193_XENLA (315-467): 1.67e-37: 138: 21.74
+	Sc
		698847 GSP1_YEAST (1-214): 5.23e-83: 247: 80.56		YRB1_YEAST (295-467): 3.08e-34: 129: 21.23
+	Sc
		698835 GSP1_YEAST (1-214): 5.23e-83: 247: 80.56		YRB2_YEAST (182-467): 2.35e-31: 124: 15.67
+	Ce
		184995 RAN_CAEEL (3-205): 3.44e-97: 283: 88.18		Q86G90_CAEEL (257-465): 7.57e-17: 85.6: 13.81
+	Sp
		660086 SPI1_SCHPO (1-214): 1.23e-84: 251: 80.84		RANG_SCHPO (292-467): 1.44e-29: 116: 19.23