HitPredict

Interactor 1: BCAR1 (P56945)
Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas)
Gene: BCAR1

Interactor 2: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	11071869, 12618476
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0007015 - actin filament organization GO:0016477 - cell migration and 1 others more... GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 665
+	Hs
		942982 BCAR1_HUMAN (1-870): 1.95e-107: 353: 100.00		CD2AP_HUMAN (1-664): 1.84e-95: 309: 32.36
+	Hs
		1462487 MACF1_HUMAN (505-867): 2.95e-74: 268: 13.79		CD2AP_HUMAN (1-664): 1.84e-95: 309: 32.36
+	Hs
		1251262 DNMBP_HUMAN (7-561): 3.15e-28: 125: 14.87		SH3K1_HUMAN (1-665): 1.57e-126: 391: 100.00
+	Hs
		942612 BCAR1_HUMAN (1-870): 1.95e-107: 353: 100.00		CASL_HUMAN (2-656): 2.59e-38: 154: 11.91
+	Hs
		942540 BCAR1_HUMAN (1-870): 1.95e-107: 353: 100.00		GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37
+	Hs
		593951 BCAR1_HUMAN (1-870): 1.95e-107: 353: 100.00		NCK1_HUMAN (104-413): 3.74e-26: 112: 16.62
+	Hs
		1127339 CASL_HUMAN (1-868): 5.72e-90: 305: 35.85		CASL_HUMAN (2-656): 2.59e-38: 154: 11.91
+	Hs
		222046 BCAR1_HUMAN (1-870): 1.95e-107: 353: 100.00		NCK2_HUMAN (244-432): 3.03e-17: 86.2: 21.24
+	Hs
		593997 CASL_HUMAN (1-868): 5.72e-90: 305: 35.85		NCK1_HUMAN (104-413): 3.74e-26: 112: 16.62
+	Hs
		987557 DYST_HUMAN (457-866): 1.24e-66: 245: 12.07		GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37
+	Hs
		1040304 DYST_HUMAN (457-866): 1.24e-66: 245: 12.07		ITSN1_HUMAN (77-423): 3.02e-14: 78.9: 14.56
+	Hs
		1040391 DYST_HUMAN (457-866): 1.24e-66: 245: 12.07		ITSN2_HUMAN (214-418): 8.13e-14: 77.4: 15.61
+	Hs
		590268 MUC1_HUMAN (53-766): 3.75e-35: 146: 11.68		GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37
+	Hs
		987579 ACK1_HUMAN (9-499): 5.89e-30: 130: 15.35		GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37
+	Hs
		593976 ACK1_HUMAN (9-499): 5.89e-30: 130: 15.35		NCK1_HUMAN (104-413): 3.74e-26: 112: 16.62
+	Mm
		236934 ACK1_MOUSE (9-581): 2.89e-29: 127: 13.93		NCK1_MOUSE (104-413): 1.87e-26: 113: 16.92
+	Hs
		1251245 DNMBP_HUMAN (7-561): 3.15e-28: 125: 14.87		DNMBP_HUMAN (4-581): 5.37e-24: 110: 12.50
+	Hs
		222066 ACK1_HUMAN (9-499): 5.89e-30: 130: 15.35		NCK2_HUMAN (244-432): 3.03e-17: 86.2: 21.24
+	Mm
		236904 ACK1_MOUSE (9-581): 2.89e-29: 127: 13.93		SRBS1_MOUSE (3-155): 1.1e-13: 77: 34.15
+	Hs
		274251 ANR17_HUMAN (69-494): 5.56e-27: 121: 14.82		ITSN2_HUMAN (214-418): 8.13e-14: 77.4: 15.61