HitPredict

Interactor 1: D4A6C6 (D4A6C6)
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1)
Gene: Tab1

Interactor 2: G3V617 (G3V617)
Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha)
Gene: Mapk14

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	16407200, 21607062
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PP2C~Pkinase
Common GO terms	GO:0005829 - cytosol GO:0048273 - mitogen-activated protein kinase p38 binding
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 492 Rn			1 360
+	Mm
		867759 TAB1_MOUSE (2-492): 4.75e-175: 503: 97.76		MK14_MOUSE (1-360): 2.52e-157: 447: 99.72
+	Hs
		1153034 TAB1_HUMAN (2-492): 5.63e-173: 498: 96.15		MK14_HUMAN (1-360): 6.9e-157: 446: 99.17
+	Hs
		923351 TAB1_HUMAN (2-492): 5.63e-173: 498: 96.15		MK12_HUMAN (1-351): 3.49e-146: 419: 62.99
+	Hs
		1153033 TAB1_HUMAN (2-492): 5.63e-173: 498: 96.15		MK11_HUMAN (1-348): 1.83e-144: 414: 75.86
+	Hs
		1025267 TAB1_HUMAN (2-492): 5.63e-173: 498: 96.15		CDK3_HUMAN (21-323): 7.07e-140: 401: 36.25
+	Hs
		853688 TAB1_HUMAN (2-492): 5.63e-173: 498: 96.15		MK08_HUMAN (2-348): 2.41e-108: 325: 47.11
+	Hs
		776963 PPM1A_HUMAN (20-371): 5.94e-89: 279: 14.33		MK14_HUMAN (1-360): 6.9e-157: 446: 99.17
+	Rn
		633962 PPM1A_RAT (20-371): 1.94e-89: 280: 14.33		MK03_RAT (14-350): 1.49e-144: 415: 48.55
+	Hs
		290859 PPM1B_HUMAN (20-468): 5.49e-86: 274: 14.05		CDK2_HUMAN (21-316): 2.33e-147: 419: 36.76
+	Rn
		64473 A6H9I0_RAT (20-387): 2.36e-85: 272: 15.32		MK03_RAT (14-350): 1.49e-144: 415: 48.55
+	Dm
		823701 Q9W0Q0_DROME (4-360): 3.25e-86: 270: 16.39		ERKA_DROME (2-349): 1.84e-142: 410: 48.45
+	Hs
		703462 PPM1A_HUMAN (20-371): 5.94e-89: 279: 14.33		MK01_HUMAN (10-350): 5.53e-137: 395: 47.99
+	At
		1183783 P2C30_ARATH (27-296): 3.42e-23: 103: 22.46		MPK4_ARATH (1-352): 1.17e-148: 426: 48.46
+	At
		1183655 P2C30_ARATH (27-296): 3.42e-23: 103: 22.46		MPK3_ARATH (1-351): 6.02e-143: 411: 45.23
+	At
		1184055 P2C30_ARATH (27-296): 3.42e-23: 103: 22.46		MPK6_ARATH (3-351): 2.79e-140: 405: 45.48