HitPredict

Interactor 1: AFAD (P55196)
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)
Gene: AFDN

Interactor 2: MINK1 (Q8N4C8)
Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6)
Gene: MINK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FHA~Pkinase
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1824 Hs			1 1332
+	Hs
		348083 AFAD_HUMAN (1-1824): 0: 1266: 100.00		M4K4_HUMAN (1-1332): 0: 1044: 57.66
+	Hs
		936370 AFAD_HUMAN (1-1824): 0: 1266: 100.00		MARK2_HUMAN (8-748): 5.62e-140: 448: 14.84
+	Hs
		692020 AFAD_HUMAN (1-1824): 0: 1266: 100.00		MARK3_HUMAN (16-748): 1.46e-133: 430: 14.72
+	Mm
		1223753 DLG4_MOUSE (952-1591): 2.35e-24: 113: 11.13		MINK1_MOUSE (1-1332): 0: 1250: 93.46
+	Hs
		1085119 KIF1A_HUMAN (183-586): 1.29e-58: 226: 15.08		TNIK_HUMAN (1-1332): 0: 1110: 60.76
+	Mm
		1013688 DLG2_MOUSE (936-1152): 2.54e-34: 145: 23.77		TNIK_MOUSE (1-1332): 0: 1125: 62.53
+	Mm
		1013596 DLG4_MOUSE (952-1591): 2.35e-24: 113: 11.13		TNIK_MOUSE (1-1332): 0: 1125: 62.53
+	Mm
		999781 DLG3_MOUSE (867-1244): 1.79e-19: 97.7: 15.52		TNIK_MOUSE (1-1332): 0: 1125: 62.53
+	Mm
		1013694 MYO5A_MOUSE (1414-1824): 1.15e-15: 85.7: 12.42		TNIK_MOUSE (1-1332): 0: 1125: 62.53
+	Hs
		1270537 KI13B_HUMAN (184-691): 2.15e-62: 238: 13.13		MARK2_HUMAN (8-748): 5.62e-140: 448: 14.84
+	Hs
		1140625 KIF14_HUMAN (175-624): 1.61e-57: 222: 18.72		MYO3B_HUMAN (13-329): 8.37e-114: 390: 47.71
+	Hs
		1097668 KIF14_HUMAN (175-624): 1.61e-57: 222: 18.72		STK3_HUMAN (3-507): 4.74e-120: 384: 30.12
+	Hs
		1093109 KIF14_HUMAN (175-624): 1.61e-57: 222: 18.72		STK4_HUMAN (5-469): 4.05e-119: 382: 32.99
+	Hs
		1140969 KIF14_HUMAN (175-624): 1.61e-57: 222: 18.72		STK26_HUMAN (20-413): 7.89e-114: 365: 37.37
+	Rn
		723891 DLG4_RAT (1002-1238): 1.5e-27: 123: 17.12		M3K11_RAT (26-746): 4.21e-133: 431: 22.05
+	Hs
		692052 PTN13_HUMAN (978-1091): 1.19e-17: 92.2: 35.83		MARK3_HUMAN (16-748): 1.46e-133: 430: 14.72
+	Hs
		1006073 DLG4_HUMAN (1002-1238): 1.76e-27: 123: 17.12		M3K11_HUMAN (26-779): 2.14e-120: 397: 21.38
+	Hs
		1006049 DLG4_HUMAN (1002-1238): 1.76e-27: 123: 17.12		M3K10_HUMAN (21-845): 1.73e-113: 381: 19.26
+	Hs
		138826 PTN13_HUMAN (978-1091): 1.19e-17: 92.2: 35.83		STK25_HUMAN (20-413): 2.16e-119: 380: 37.37
+	Hs
		1090197 PTN13_HUMAN (978-1091): 1.19e-17: 92.2: 35.83		STK26_HUMAN (20-413): 7.89e-114: 365: 37.37