HitPredict

Interactor 1: EZH1 (P70351)
Histone-lysine N-methyltransferase EZH1 (EC 2.1.1.356) (ENX-2) (Enhancer of zeste homolog 1)
Gene: EZH1

Interactor 2: AEBP2 (Q9Z248)
Zinc finger protein AEBP2 (Adipocyte enhancer-binding protein 2) (AE-binding protein 2)
Gene: AEBP2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	25680957, 20064376
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0035098 - ESC/E(Z) complex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 747 Mm			1 504
+	Hs
		1168986 EZH1_HUMAN (1-747): 0: 841: 97.86		AEBP2_HUMAN (1-496): 1.88e-133: 398: 88.34
+	Mm
		1142303 EZH2_MOUSE (8-746): 0: 708: 63.29		AEBP2_MOUSE (12-504): 4.05e-137: 407: 100.00
+	Hs
		1080051 EZH2_HUMAN (8-746): 0: 704: 63.03		AEBP2_HUMAN (1-496): 1.88e-133: 398: 88.34
+	Mm
		1149808 Q6AXH7_MOUSE (8-746): 0: 684: 62.48		AEBP2_MOUSE (12-504): 4.05e-137: 407: 100.00
+	Dm
		785630 EZ_DROME (8-747): 0: 692: 49.56		JING_DROME (256-473): 1.39e-90: 304: 34.09
+	Hs
		632837 EZH1_HUMAN (1-747): 0: 841: 97.86		TYY1_HUMAN (256-378): 1.18e-19: 92.9: 21.95
+	Mm
		962542 EZH2_MOUSE (8-746): 0: 708: 63.29		TYY1_MOUSE (256-378): 7.39e-20: 93.7: 21.95
+	Hs
		632750 EZH2_HUMAN (8-746): 0: 704: 63.03		TYY1_HUMAN (256-378): 1.18e-19: 92.9: 21.95
+	Dm
		785631 EZ_DROME (8-747): 0: 692: 49.56		PHO_DROME (247-350): 3.83e-19: 92.1: 28.85
+	Hs
		1080129 EZH2_HUMAN (8-746): 0: 704: 63.03		ZN397_HUMAN (192-280): 3.9e-09: 61: 15.73
+	Hs
		599072 SETD2_HUMAN (137-733): 6e-64: 234: 15.71		ZNF10_HUMAN (176-388): 2.79e-46: 171: 13.36
+	Dm
		1180545 TRR_DROME (612-733): 3.82e-19: 95.1: 41.46		JING_DROME (256-473): 1.39e-90: 304: 34.09
+	Hs
		1317718 NSD3_HUMAN (471-730): 5.19e-55: 207: 25.46		GLIS2_HUMAN (188-388): 2.59e-36: 142: 21.96
+	Hs
		203697 SUV91_HUMAN (397-732): 1.58e-73: 246: 22.19		ZN829_HUMAN (331-472): 3.87e-20: 94.5: 7.90
+	Hs
		632914 EHMT1_HUMAN (419-733): 1.83e-68: 247: 23.03		TYY1_HUMAN (256-378): 1.18e-19: 92.9: 21.95
+	Hs
		632859 EHMT2_HUMAN (443-733): 2.21e-67: 244: 23.85		TYY1_HUMAN (256-378): 1.18e-19: 92.9: 21.95
+	Hs
		632699 KMT2A_HUMAN (620-734): 4.36e-19: 95.1: 42.24		TYY1_HUMAN (256-378): 1.18e-19: 92.9: 21.95
+	Hs
		165629 SET1A_HUMAN (612-733): 1.18e-18: 93.6: 39.52		TYY1_HUMAN (256-378): 1.18e-19: 92.9: 21.95